COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS^*

Robert F. Furchgott,

Robert F. Furchgott

Department of Pharmacology, State University of New York Downstate Medical Center, Brookiyn, N. Y.

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Paula Bursztyn,

Paula Bursztyn

Department of Pharmacology, State University of New York Downstate Medical Center, Brookiyn, N. Y.

Pre-doctoral trainee under U.S.P.H.S. Pharmacology Training Grant 5 TI-GM-163.

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Robert F. Furchgott,

Robert F. Furchgott

Department of Pharmacology, State University of New York Downstate Medical Center, Brookiyn, N. Y.

Search for more papers by this author

Paula Bursztyn,

Paula Bursztyn

Department of Pharmacology, State University of New York Downstate Medical Center, Brookiyn, N. Y.

Pre-doctoral trainee under U.S.P.H.S. Pharmacology Training Grant 5 TI-GM-163.

Search for more papers by this author

First published: October 1967

https://doi.org/10.1111/j.1749-6632.1967.tb53817.x

Citations: 445

The research reported here was supported by a grant from The Life Insurance Medical Research Fund.

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References

Ariens, E. J. 1964. Molecular Pharmacology. 1: Academic Press, Inc. New York , N. Y. .
Beckett, A. H., N. J. Harper & J. W. Clitherow. 1963. The importance of stereoisomerism in muscarinic activity. J. Pharm. Pharmacol. 15: 362–371.
Belleau, B. 1965. Conformational perturbation in relation to the regulation of enzyme and receptor behavior. In Advances in Drug Research. N. J. Harper and A. B. Simmonds, Eds. 2: 89–126. Academic Press, Inc. New York , N. Y. .
Furchgott, R. F. 1964. Receptor mechanisms. Ann. Rev. Pharmacol. 4: 21–50.
Furchgott, R. F. 1966. The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. In Advances in Drug Research. N. J. Harper, and A. B. Simmonds, Eds. 3: 21–55. Academic Press, Inc. New York , N. Y. .
Mackay, D. 1966. A general analysis of the receptor-drug interaction. Brit. J. Pharmacol. 26: 9–16.
Paton, W. D. M. 1961. A theory of drug action based on the rate of drug-receptor combination. Proc. Roy. Soc. B. 154: 21–69.
Stephenson, R. P. 1956. A modification of receptor theory. Brit. J. Pharmacol. 11: 379–393.
Van Rossum, J. M. 1962. Pharmacodynamics of parasympathetic drugs: mechanism of action and structure-action relationship of tertiary ammonium salts. Arch. Int. Pharmacodyn. 140: 592–605.

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Volume144, Issue2

Cholinergic Mechanisma

October 1967

Pages 882-899

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS^*

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COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

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COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS^*