Basic Fibroblast Growth Factor in Neurons and Its Putative Functionsa
K. UNSICKER,
C. GROTHE,
D. OTTO,
R. WESTERMANN,
K. UNSICKER
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorC. GROTHE
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorD. OTTO
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorR. WESTERMANN
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorK. UNSICKER,
C. GROTHE,
D. OTTO,
R. WESTERMANN,
K. UNSICKER
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorC. GROTHE
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorD. OTTO
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authorR. WESTERMANN
Department of Anatomy and Cell Biology University of Marburg D-3550 Marburg, Germany
Search for more papers by this authora
Research from our laboratory described in this article was supported by grants from Deutsche Forschungsgemeinschaft, BMFT, and Fonds der Chemischen Industrie.
References
- 1
Unsicker. K.,
D. Blottner,
D. Dreyer,
C. Grothe,
A. Lagrange,
D. Otto &
R. Westermann. 1990. Basic FGF and its implications for physiological and lesion-induced neuron death. In
Regulation of Gene Expression in the Nervous System. J. De Vellis,
R. Perez-Polo,
A. M. Giuffrida Stella, Eds.: 31–47. Allan R. Liss.
New York
,
N.Y
.
- 2
Unsicker, K.,
C. Grothe,
G. Ludecke,
D. Otto &
R. Westerman.
Fibroblast growth factors: their roles in the central and peripheral nervous system. Neurotrophic Factors. S. E. Loughlin &
J. H. Fallon, Eds.
Academic Press.
New York
,
N.Y.
(In press).
- 3
Walicke, P.
1989. Novel neurotrophic factors, receptors and oncogenes.
Annu. Rev. Neurosci.
12: 103–126.
- 4
Walicke, P.
1990. Fibroblast growth factor (FGF): a multifunctional growth factor in the CNS.
Adv. Neural Regeneration Res.: 103–114.
- 5
Westermann, R.,
C. Grothe &
K. Unsicker. 1990. Basic fibroblast growth factor (bFGF), a multifunctional growth factor for neuroectodermal cells.
J. Cell Sci. Suppl.
13: 97–117.
- 6
Gospodarowicz, D.,
G. Neufeld &
L. Schweigerer. 1986. Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells.
Cell Differ.
19: 1–17.
- 7
Risau, W.,
P. Gautschi-Sova &
P. Bohlen. 1988. Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.
EMBO J.
7: 959–926.
- 8
Presta, M.,
M. Rusnati,
J. A. M. Maier &
G. Ragnoti. 1988. Purification of basic fibroblast growth factor from rat brain: identification of a Mr 22,000 immunoreactive form.
Biochem. Biophys. Res. Commun.
155: 1161–1172.
- 9
Pettmann, B.,
G. Labourdette,
M. Weibel &
M. Sensenbrenner. 1986. The brain fibroblast growth factor (FGF) is localized in neurons.
Neurosci. Lett.
68: 175–180.
- 10
Janet, T.,
M. Miehe,
B. Pe-Itmann,
G. Labourdette &
M. Sensenbrenner. 1987. Ultrastructural localization of fibroblast growth factor in neurons of rat brain.
Neurosci. Lett.
80: 153–157.
- 11
Gonzales, A. M.,
M. Buscaglia,
M. Ong &
A. Baird. 1990. Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.
J. Cell Biol.
110: 753–765.
- 12
Grortte. C. &
K. Unsicker. 1990. Immunocytochemical mapping of basic fibroblast growth factor in the developing and adult rat adrenal gland.
Histochemistry
94: 141–147.
- 13
Emoto, N.,
A. M. Gonzales,
P. A. Walicke,
E. Wada,
D. M. Simmons,
S. Shimasaki &
A. Baird. 1989. Basic fibroblast growth factor (FGF) in the central nervous system: identification of specific loci of basic FGF expression in the rat brain.
Growth Factors
2: 21–29.
- 14
Schnurch, H. &
W. Risau.
Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development.
EMBO J. (In press.).
- 15
Ferrara, N.,
F. Ousley &
D. Gospodarowicz. 1988. Bovine brain astrocytes express basic fibroblast growth factor, a neurotrophic and angiogenic mitogen.
Brain Res.
462: 223–323.
- 16
Grothe, C.,
K. Zachmann &
K. Unsicker. 1991. Basic FGF-like immunoreactivity in the developing and adult rat brain stem.
J. Comp. Neurol.
305: 328–336.
- 17
Ishikawa, R.,
K. Nishikori &
S. Furukawa.
Developmental changes in distribution of acidic fibroblast growth factor in rat brain evaluated by a sensitive twosite enzyme immunoassay.
J. Neurochem. (In press.).
- 18
Kalcheim. C. &
G. Neufeld. 1990. Expression of basic fibroblast growth factor in the nervous system of early avian embryos.
Development
109: 203–215.
- 19
Nieto-Sampedro, M.,
R. Lim,
D. I. Hicklin &
C. W. Cotman. 1988. Early release of glial maturation factor and acidic fibroblast growth factor after rat brain injury.
Neurosci. Lett.
86: 361–365.
- 20
Ishikawa, R.,
K. Nishikori &
S. Furukawa.
Appearance of nerve growth factor and acidic fibroblast growth factor with different time courses in the cavity-lesioned cortex of the rat brain.
Neurosci. Lett. (In press.).
- 21
Finklestein, S. P.,
P. J. Apostolides,
C. G. Caday,
J. Prosser,
M. F. Philips &
M. Klagsbrun. 1988. Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds.
Brain Res.
460: 253–259.
- 22
Walicke, P.
1989. Novel neurotrophic factors, receptors, and oncogenes.
Annu. Rev. Neurosci.
12: 103–126.
- 23
Heuer, J. G.,
C. S. Von Bartheld,
Y. Kinoshita,
P. C. Evers &
M. Bothwell. 1990. Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system.
Neuron
5: 283–296.
- 24
Bartlett, P. F.,
H. H. Reid,
K. A. Bailey &
O. Bernard. 1988. Immortalization of mouse neural precursor cells by the c-myc oncogene.
Proc. Nat. Acad. Sci. USA
85: 3255–3259.
- 25
Gensburger, C.,
G. Labourdette &
M. Sensenbrenner. 1987. Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vivo.
FEBS Lett.
217: 1–5.
- 26
Cattaneo. E. &
R. McKay. 1990. Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor.
Nature
347: 762–765.
- 27
Wanaka, A.,
M. Johnson Jr. &
J. Milbrandt. 1990. Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization.
Neuron
5: 267–281.
- 28
Walicke, P.,
W. M. Cowan,
N. Ueno,
A. Baird &
R. Guillemin. 1986. Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.
Proc. Nat. Acad. Sci. USA
83: 3012–3016.
- 29
Morrison, R. S.,
A. Sharma,
J. De Vellis &
R. A. Bradshaw.
Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.
Proc. Nat. Acad. Sci. USA
83: 7537–7541.
- 30
Walicke, P.
1988. Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions.
J. Neurosci.
8: 2618–2627.
- 31
Unsicker, K.,
H. Reichert-Preibsch,
R. Schmidt,
B. Pettmann,
G. Labourdeite &
M. Sensenbrenner. 1987. Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.
Proc. Nat. Acad. Sci. USA
84: 5459–5463.
- 32
Peitmann, B.,
M. Weibel,
M. Sensenbrenner &
G. Labourdette. 1985. Purification of two astroglial growth factors from bovine brain.
FEBS Lett.
189: 102–108.
- 33
Weibel, M.,
M. Pettmann,
G. Labourdette,
M. Miehe,
E. Bock &
M. Sensenbrenner. 1985. Morphological and biochemical maturation of rat astroglial cells grown in a chemically defined medium: influence of an astroglial growth factor.
Int. J. Dev. Neurosci.
3: 617–630.
- 34
Rogister, B.,
P. Leprince,
B. Pettmann,
G. Labourdette,
M. Sensenbrenner &
G. Moonen. 1988. Brain basic fibroblast growth factor stimulates the release of plasminogen activators by newborn rat cultured astroglial cells.
Neurosci. Lett.
91: 321–326.
- 35
Saneto, R. P. &
J. De Vellis. 1985. Characterization of cultured rat oligodendrocytes proliferating in a serum-free, chemically defined medium.
Proc. Nat. Acad. Sci. USA
82: 3509–3513.
- 36
Eccleston, P. A. &
D. H. Silberberg. 1985. Fibroblast growth factor is a mitogen for oligodendrocytes in vitro.
Dev. Brain Res.
21: 315–318.
- 37
Besnard, F.,
F. Perraud,
M. Sensenbrenner &
G. Labourdette. 1989. Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes.
Int. J. Dev. Neurosci.
7: 401–409.
- 38
Pruss, R. M.,
P. F. Bartlett,
J. Gavrilovic,
R. P. Lisak &
S. Rattray. 1981. Mitogens for glial cells: a comparison of the response of cultured astrocytes, oligodendrocytes and Schwann cells.
Brain Res.
254: 19–35.
- 39
Dreyer, D.,
A. Lagrange,
C. Grothe &
K. Unsicker. 1989. Basic fibroblast growth factor prevents ontogenetic neuron death in vivo.
Neurosci. Lett.
99: 35–38.
- 40
Hendry, I. A.,
D. A. Belford,
M. F. Crouch &
C. E. Hill. 1990. Parasympathetic neurotrophic factors.
Int. J. Dev. Neurosci. Abstr. 8th Biennial Meeting, Int. Soc. Devl. Neuroscience, June 16-22, Bal Harbor, Florida.
- 41
Oppenheim, R. W.,
D. Prevette &
F. H. Fuller. 1990. In vivo treatment with basic fibroblast growth factor during development does not alter naturally occuring neuronal death.
Soc. Neurosci. Abstr.
16: 1135.
- 42
Otto, D.,
K. Unsicker &
C. Grothe. 1987. Pharmacological effects of nerve growth factor and fibroblast factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia.
Neurosci. Lett.
83: 156–160.
- 43
Otto, D.,
D. Frotscher &
K. Unsicker. 1989. Basic fibroblast growth factor administered in gel foam rescue medial septal neurons after fimbria fornix transections.
J. Neurosci. Res.
22: 83–91.
- 44
Anderson, K. J.,
D. Dam,
S. Lee &
C. W. Cotman. 1988. Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo.
Nature
332: 360–362.
- 45
Williams, L. R.,
S. Varon,
G. M. Peterson,
K. Wictorin,
W. Fischer,
A. Björklund &
F. H. Gage. 1986. Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.
Proc. Nat. Acad. Sci. USA
83: 9231–9235.
- 46
Ferguson, I. A.,
J. B. Schweitzer &
E. M. Johnson, Jr. 1990. Basic fibroblast growth factor: receptor-mediated internalization, metabolism, and anterograde axonal transport in retinal ganglion cells.
J. Neurosci.
10: 2176–2189.
- 47
Ferguson, I. A.,
A. Wanaka &
E. M. Johnson, Jr. 1990. bFGF undergoes receptormediated retrograde transport in CNS neurons.
Soc. Neurosci. Abstr.: 824.
- 48
Sievers, J.,
B. Hausmann,
K. Unsicker &
M. Berry. 1987. Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve.
Neurosci. Lett.
76: 157–162.
- 49
Otto. D. &
K. Unsicker. 1990. Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice.
J. Neurosci.
10: 1912–1921.
- 50
Blottner, D.,
R. Westermann,
C. Grothe,
P. Bohlen &
K. Unsicker. 1989. Basic fibroblast growth factor in the adrenal gland.
Eur. J. Neurosci.
1: 417–478.
- 51
Blottner. D. &
K. Unsicker. 1990. Maintenance of intermediolateral spinal cord neurons by fibroblast growth factor administered to the medullectomized rat adrenal gland: dependence on intact adrenal innervation and cellular organization of implants.
Eur. J. Neurosci.
2: 378–382.
- 52
Barde, Y. A.
1989. Trophic factors and neuronal survival.
Neuron
2: 1525–1534.
- 53
Oppenheim, R. W.
1989. The neurotrophic theory and naturally occuring motoneuron death.
TINS
12: 252–255.
- 54
Guesch, A.,
E. Hartmann,
K. Rohde,
A. Rubartelli,
R. Sitia &
T. A. Rapoport. 1990. A novel pathway for secretory proteins?
TIBS
15: 86–88.
- 55
Terlau. H. &
W. Seifert. 1990. Fibroblast growth factor enhances long-term potentiation in the hippocampal slice.
Eur. J. Neurosci.
2: 973–977.
Citing Literature
