Crystal and Solution Structures of d(CGC[e6G]AATTCGCG)-Drug Complexes Reveal Conformational Polymorphism of O6-Ethyl-Guanine:Cytosine Base Paira
M. SRIRAM
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorD. YANG
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorY.-G. GAO
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorCorresponding Author
ANDREW H.-J. WANG
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
To whom correspondence should be addressed.Search for more papers by this authorM. SRIRAM
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorD. YANG
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorY.-G. GAO
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
Search for more papers by this authorCorresponding Author
ANDREW H.-J. WANG
Department of Cell and Structural Biology University of Illinois at Urbana-Champaign Urbana, Illinois 61801
To whom correspondence should be addressed.Search for more papers by this authorThis work was supported by National Institutes of Health Grants GM-41612 and CA-52506 (A.H.-J.W.).
References
- 1
Singer, B.,
W. L. Bodell,
J. E. Cleaver,
G. H. Thomas &
M. F. Rajewsky
1978. Nature
276: 85–88.
- 2
Thomale, J.,
N.-H. Huh,
P. Nehls,
G. Eberle &
M. F. Rajewsky
1990. Proc. Natl. Acad. Sci. USA
87: 9883–9887.
- 3
Loechler, E. L.,
C. L. Green &
J. M. Essigmann
1984. Proc. Natl. Acad. Sci. USA
81: 6271–6275.
- 4
Ellison, K. S.,
E. Dogliotti,
T. D. Connors,
A. K. Basu &
J. M. Essigmann
1989. Proc. Natl. Acad. Sci. USA
86: 8620–8624.
- 5
Lindahl, T.,
B. Sedgwick,
M. Sekiguchi &
Y. Nakabeppu
1988. Annu. Rev. Biochem.
57: 133–158.
- 6
Leonard, G. A.,
J. Thomson,
W. P. Watson &
T. Brown
1990. Proc. Natl. Acad. Sci. USA
87: 9573–9576.
- 7
Pedersen, L. G.,
T. A. Darden,
D. W. Deerfield,
M. W. Anderson &
D. G. Hoel
1990. Carcinogenesis
9: 1553–1562.
- 8
Parthasarathy, R. &
S. M. Fridey
1986. Carcinogenesis
7: 221–227.
- 9
Ginell, S. L.,
S. Kuzmich,
R. A. Jones &
H. M. Berman
1990. Biochemistry
29: 10461–10465.
- 10
Patel, D. J.,
L. Shapiro,
S. A. Kozlowski,
B. L. Gaffney &
R. A. Jones
1986. Biochemistry
25: 1027–1036.
- 11
Sriram, M.,
G. A. Van Der Marel,
H. C. P. F. Roelen,
J. H. Van Boom &
A. H.-J. Wang
1992. EMBO J. 11: 225–232.
- 12
Sriram, M.,
G. A. Van Der Marel,
H. C. P. F. Roelen,
J. H. Van Boom &
A. H.-J. Wang
1992. Biochemistry
31: 11823–11834.
- 13
Gao, Y.-G.,
M. Sriram,
W. A. Denny &
A. H.-J. Wang
1993. Biochemistry. In press.
- 14
Wang, A. H.-J. &
M.-K. Teng
1990. In
Crystallographic and Modeling Methods in Molecular Design. S. E. Ealick, Eds.: 123–150. Springer-Verlag.
New York
,
NY.
.
- 15
Kopka, M. L. &
T. A. Larsen
1992. In
Nucleic Acid Targeted Drug Design. T. J. Perun, Eds.: 303–374. Marcel Dekker.
New York
,
NY.
.
- 16
Wang, A. H.-J.,
Y. C. Liaw,
H. Robinson &
Y. G. Gao
1990. In
23rd Jerusalem Symposium in Quantum Chemistry and Biochemistry. J. Jortner, Eds.: 1–21. Kluwer Academic Publishers.
Dordrecht
,
Holland
.
- 17
Coll, M.,
S. E. Sherman,
D. Gibson,
S. J. Lippard &
A. H.-J. Wang
1990. J. Biomol. Struct. Dyn.
8: 315–330.
- 18
Aymami, J.,
M. Coll,
G. A. Van Der Marel,
J. H. Van Boom,
A. Rich &
A. H.-J. Wang
1990. Proc. Natl. Acad. Sci. USA
87: 2526–2530.
- 19
Loontiens, F. G.,
L. W. Mclaughlin,
S. Diekmann &
R. M. Clegg
1991. Biochemistry
30: 182–189.
- 20
Parkinson, J. A.,
J. Barber,
K. T. Douglas,
J. Rosamond &
D. Sharples
1990. Biochemistry
29: 10181–10190.
- 21
Fede, A.,
A. Labhardt,
W. Bannwarth &
W. Leupin
1991. Biochemistry
30: 11377–11388.
- 22
Embrey, K. J.,
M. S. Searle &
D. J. Craik
1993. Eur. J. Biochem.
211: 437–447.
- 23
Teng, M.-K.,
N. Usman,
C. A. Frederick &
A. H.-J. Wang
1988. Nucleic Acids Res. 16: 2671–2690.
- 24
Quintana, J. R.,
A. A. Lipanov &
R. E. Dickerson
1991. Biochemistry
30: 10294–10306.
- 25
Carrondo, M.,
M. Coll,
J. Aymami,
A. H.-J. Wang,
G. A. Van Der Marel,
J. H. Van Boom &
A. Rich
1989. Biochemistry
28: 7849–7859.
- 26
Leupin, W.,
W. J. Chazin,
S. Hyberts,
W. A. Denny &
K. Wuthrich
1986. Biochemistry
25: 5902–5908.
- 27
Chen, S.-M.,
W. Leupin,
M. Rance &
W. J. Chazin
1992. Biochemistry
31: 4406–4413.
- 28
Williams, L. D. &
B. R. Shaw
1987. Proc. Natl. Acad. Sci. USA
84: 1779–1783.
- 29
Frederick, C. A.,
G. J. Quigley,
G. A. Van Der Marel,
J. H. Van Boom,
A. H.-J. Wang &
A. Rich
1988. J. Biol. Chem.
263: 17872–17879.
- 30
Kalnik, M. W.,
B. F. L. Li,
P. F. Swann &
D. J. Patel
1989. Biochemistry
28: 6170–6181.
- 31
Kalnik, M. W.,
B. F. L. Li,
P. F. Swann &
D. J. Patel
1989. Biochemistry
28: 6182–6192.
- 32
Robinson, H. &
A. H.-J. Wang
1992. Biochemistry
31: 3524–3533.
- 33
Brunger, A.
1992. X-PLOR, Version 3.0. The Howard Hughes Medical Institute and Yale University.
New Haven
,
CT.
.
- 34
Jaishree, T. N.,
G. A. Van Der Marel,
J. H. Van Boom &
A. H.-J. Wang
1993. Biochemistry
32: 4903–4911.
