Neuronal Nicotinic Receptor Subtypes
JON LINDSTROM,
RENÉ ANAND,
XIAO PENG,
VOLODYMYR GERZANICH,
FAN WANG,
YUEBTNG LI,
JON LINDSTROM
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorRENÉ ANAND
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorXIAO PENG
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorVOLODYMYR GERZANICH
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorFAN WANG
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorYUEBTNG LI
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorJON LINDSTROM,
RENÉ ANAND,
XIAO PENG,
VOLODYMYR GERZANICH,
FAN WANG,
YUEBTNG LI,
JON LINDSTROM
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorRENÉ ANAND
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorXIAO PENG
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorVOLODYMYR GERZANICH
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorFAN WANG
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this authorYUEBTNG LI
Department of Neuroscience Medical School of the University of Pennsylvania Philadelphia, Pennsylvania 19104–6074
Search for more papers by this author
REFERENCES
- 1 Betz , H. 1990. Ligand-gated ion channels in the brain: The amino acid receptor superfamily. Neuron 5: 383–392.
- 2 Barnard , E. 1992. Receptor classes and the transmitter-gated ion channels. TIBS 17: 368–374.
- 3 Seeburg , P. 1993. The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16: 359–364.
- 4 Lindstrom , J., G. Shelton & Y. Fujii. 1988. Myasthenia gravis. Adv. Immunol. 42: 233–284.
- 5 Wonacott , S., M. Russell & I. Stolerman. 1990. Nicotine Psychopharmacology: Molecular, Cellular, and Behavioral Aspects. Oxford Science Publications, Oxford , UK .
- 6 Peto , R., A. Lopez, J. Boreham, M. Thun & C. Heath. 1992. Mortality from tobacco in developed countries: Indirect estimation from national vital statistics. Lancet 339: 1268–1278.
- 7 Lindstrom , J. 1994. Nicotine acetylcholine receptors. In CRC Handbook of Receptors. Alan North, Ed.: 153–176. CRC Press. Boca Raton , FL .
- 8 Karlin , A. 1993. Structure of nicotinic acetylcholine receptors. Curr. Opin. Neurobiol. 3: 299–309.
- 9 Sargent , P. 1993. The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16: 403–443.
- 10 Das , M. & J. Lindstrom. 1991. Epitope mapping of antibodies to acetylcholine recepturs. Biochemistry 30: 2470–2477.
- 11 Schoepfer , R., S. Halvorsen, W. Conroy, P. Whiting & J. Lindstrom. 1989. Antisera against an α3 fusion protein bind to ganglion but not to brain nicotinic acetylcholine receptors. FEBS Lett. 257: 393–399.
- 12 Schoepfer , R., W. Conroy, P. Whiting, M. Gore & J. Lindstrom. 1990. Brain α-bungarotoxin-binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel superfamily. Neuron 5: 35–48.
- 13 Anand , R., L. Bason, M. Saedi, V. Gerzanich, X. Peng & J. Lindstrom. 1993. Reporter epitopes: A novel approach to examine transmembrane topology of integral memhrane proteins applied to the α1 subunit of the nicotinic acetylcholine receptor. Biochemistry 32: 9975–9984.
- 14 Anand , R. & J. Lindstrom. 1992. Chromosomal localization of seven neuronal nicotinic receptor subunit genes in humans. Genomics 13: 962–967.
- 15 Chini , B., E. Raimond, A. Elgoyhen, D. Moralli, M. Balzaretti & S. Heineman 1994. Molecular cloning and chromosomal localization of the human α7 nicotinic receptor subunit gene (CHRNA7). Genomics 19: 379–381.
- 16 Doncettestamm , L., L. Monteggia, D. Donnelly Roberts, M. Wong, J. Lee, J. Tian & T. Giordano. 1993. Cloning and sequence of the human α7 nicotinic acetylcholine receptor. Drug Dev. Res. 30: 252–256.
- 17 Lobose., C. Rudnick, M. Watson & K. Isenberg. 1989. Linkage disequilibrium study of RFLPs detected at the human muscle nicotinic acetylcholine receptor subunit genes. Am. J. Hum. Genet. 44: 522–533.
- 18 Beeson , D., S. Jeremiah, L. West, S. Povey & J. Newsome-Davis. 1990. Assignment of the human nicotinic acetylcholine receptor genes: The α and δ subunit genes to chromosome 2 and the β subunit gene to chromosome 17. Ann. Hum. Genet. 54: 199–208.
- 19 Eng , C., C. Kozak, A. Beadet & H. Zoghbi. 1991, Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics 9: 278–282.
- 20
Merlie , J.,
R. Sebbane,
S. Gardner,
E. Olson &
J. Lindstrom. 1983. The regulation of acetylcholine receptor expression in mammalian muscle.
Cold Spring Harbor Symposia on Quantitative Biology
158: 135–146.
10.1101/SQB.1983.048.01.016 Google Scholar
- 21 Tzartos , S., M. Cuno, P. Demange, H. Loutrari, A. Mamalaki, M. Marraud, I. Papadouli, C. Sakarellos & V. Tsikaris. 1991. The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies. Mol. Neurobiol. 5: 1–29.
- 22 Saedi , M., R. Anand, W. Conroy & J. Lindstrom. 1990. Determination of amino acids critical to the main immunogenic region of intact acetylcholine receptors by in vitro mutagenesis. FEBS Lett. 267: 55–59.
- 23 Blount , P. & J. Merlie. 1990. Mutational analysis of muscle nicotinic acctylcholine receptor subunit assembly. J. Cell Biol. 111: 2612–2622.
- 24 Blount , P. & J. Merlie. 1989. Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor. Neuron 3: 349–357.
- 25 Verrall , S. & Z. Hall. 1992. The N-terminal domains of acetyleholine receptor subunits contain recognition signals for the initial steps of receptor assembly. Cell 68: 23–31.
- 26 Saedi , M., W. Conroy & J. Lindstrom. 1991. Assembly of Torpedo acetylcholine receptor in Xenopus oocytes. J. Cell Biol. 112: 1007–1015.
- 27 Unwin , N. 1993. Nicotinic acetylcholine receptor at 9Å resolution. J. Mol. Biol. 229: 1101–1124.
- 28 Akabas , M., D. Stauffer, M. Xu & A. Karlin. 1992. Acetylcholine receptor channel structure probed in cysteine-substitution mutants. Science 258: 307–310.
- 29 Deneris , E., J. Connolly, S. Rogers & R. Duvoisin. 1991. Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. Trends Pharmacol. Sci. 12: 34–40.
- 30 Heinemann , S., J. Boulter, J. Connolly, E. Deneris, R. Duvoisin, M. Hartley, I. Hermans-Borgmeyer, M. Hollmann, A. O'Shea-Greenfield, A. Papke, S. Rogers & J. Patrick. 1991. The nicotinic receptor genes. Clin. Neuropharmacol. 14: S45–S61.
- 31 Whiting , P. & J. Lindstrom. 1987. Purification and characterization of a nicotinic acetylcholinc receptor from rat brain. Proc. Natl. Acad. Sci. USA 84: 595–599.
- 32 Whiting , P. & J. Lindstrom. 1988. Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies. J. Neurosci. 8: 3395–3404.
- 33 Whiting , P., R. Schoepfer, W. Conroy, M. Gore, K. Keyser, S. Shimasaki, F. Esch, L. J. Lindstrom. 1991. Differential expression of nicotinic acetylcholine receptor subtypes in brain and retina. Mol. Brain Res. 10: 61–70.
- 34 Whiting , P. & J. Lindstrom. 1986. Purification and characterization of a nicotinic acetylcholine receptor from chick brain. Biochemistry 25: 2082–2093.
- 35 Whiting , P., R. Liu, B. Morley & J. Lindstrom. 1987. Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies. J. Neurosci. 7: 4005–4016.
- 36 Nakayama , H., M. Shirase, T. Nakashima, Y. Kurogochi & J. Lindstrom. 1990. Affinity purification of nicotinic acetylcholine receptor from rat brain. Mol. Brain Res. 7: 221–226.
- 37 Nakayama , H., H. Okuda & T. Nakashima. 1993. Phosphorylation of rat brain nicotinic acetylcholine receptor by CAMP-dependent protein kinase in vitro. Mol. Brain Res. 20: 171–177.
- 38 Whiting , P., F. Esch, S. Shiasaki & J. Lindstrom. 1987. Neuronal nicotinic acetylcholine receptor p subunit is coded for by the cDNA clone α4. FEBS Lett. 219: 459–463.
- 39 Schoepfer , R., P. Whiting, F. Esch, R. Blacher, S. Shimasaki & J. Lindstrom. 1988. cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor. Neuron 1: 241–248.
- 40 Flores, G. S. Rogers, L. Pabreza, B. Wolfe & K. Kellar. 1992. A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment. Mol. Pharmacol. 41: 31–37.
- 41 Conroy , W., A. Vernallis & D. Berg. 1992. The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron 9: 1–20.
- 42 Whiting , P., R. Schoepfer, J. Lindstrom & T. Priestly. 1991. Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Mol. Pharmacol. 40: 463–472.
- 43 Pereira , E., M. Alkondon, S. Reinhardt-Maelicke, X. Peng, J. Lindstrom, P. Whiting & E. Albuquerque. 1994. Physostigmine and galanthamine reveal the presence of the novel binding site on the α4β2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells. J. Pharmacol. Exp. Ther. 270: 768–778.
- 44 Anand , R., W. Conroy, R. Schoepfer, P. Whiting & J. Lindstrom. 1991. Chicken neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J. Biol. Chem. 266: 11192–11198.
- 45 Cooper , E., S. Couturier & M. Ballivet. 1991. Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350: 235–238.
- 46 Swanson , L., D. Simmons, P. Whiting & J. Lindstrom. 1987. Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system. J. Neurosci. 7: 3334–3342.
- 47 Clarke , P., R. Schwartz, S. Paul, C. Pert & A. Pert. 1985. Nicotinic binding in rat brain: Autoradiographic comparison of [3H] nicotine, and [125I] α-bungarotoxin. J. Neurosci. 5: 1307–1315.
- 48 Hill , J., M. Zoli, J. Bourgeois & J. Changeux. 1993. Immunocytochernical localization of a neuronal nicotinic receptor: The β2 subunit. J. Neurosci. 13: 1551–1568.
- 49 Keyser , K., T. Hughes, P. Whiting, J. Lindstrom & H. Karten. 1988. Cholinoceptive neurons in the retina of the chick: An immunohistochemical study of the nicotinic acetylcholine receptors. Visual Neurosci. 1: 349–366.
- 50 Britto , L., D. Hamassaki-Britto, E. Ferro, K. Keyser, H. Karten & J. Lindstrom. 1992. Neurons of the chick brain and retina expressing both α-bungarotoxin-sensitive and α-bungarotoxin-insensitive nicotinic acetylcholine receptors: An immunohistochemical analysis. Brain Res. 590: 193–200.
- 51 Clarke , P., G. Hamill, N. Nadi, D. Jacobowitz & A. Pert. 1986. 3H-Nicotine and 125I-α-bungarotoxin-labeled nicotinic receptors in the interpeduncular nucleus of rats. II. Effects of habenular deafferentation. J. Comp. Neurol. 251: 407–413.
- 52 Britto , L., K. Keyser, J. Lindstrom & H. Karten. 1992. Immunohistochemical localization of nicotinic acetylcholine receptor subunits in the mesencephalon and diencephalon of the chick (Gallus gallus). J. Comp. Neurol. 317: 325–340.
- 53 Rapier , C., G. Lunt & S. Wonnacott. 1988. Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: Concentration dependencr and repetitive stimulation. J. Neurochem. 50: 1123–1130.
- 54 Grady , S., M. Marks & A. Collins. 1994. Desensitization of nicotine-stimulated 3H dopamine release from mouse striatal synaptosomes. J. Neurochem. 62: 1390–1398.
- 55 Marks , M., J. Pauly, D. Gross, E. Deneris, I. Hermans-Borgmeyer, S. Heimann & A. Collins. 1992. Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci. 12: 2765–2784.
- 56 Peng , X., V. Gerzanich, R. Anand, P. Whiting & J. Lindstrom. 1994. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46: 523–530.
- 57 Vernalis , A., W. Conroy & D. Berg. 1993. Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes. Neuron 10: 451–464.
- 58 Tzartos , S., D. Rand, B. Einarson & J. Lindstrom. 1981. Mapping of surface structures on Electrophorus acetylcholine receptor using monoclonal antibodies. J. Biol. Chem. 256: 8635–8645.
- 59 Anand , R. & J. Lindstrom. 1990. Nucleotide sequence of the human nicotinic acetylcholine receptor β2 subunit gene. Nucleic Acids Res. 18: 4272.
- 60 Wang , F. & J. Lindstrom. Unpublished results.
- 61 Jacob , M., D. Berg & J. Lindstrom. 1984. A shared antigenic determinant between the Electrophorus acetylcholine receptor and a synaptic component on chick ciliary ganglion neurons. Proc. Natl. Acad. Sci. USA 81: 3223–3227.
- 62 Jacob , M., J. Lindstrom & D. Berg. 1986. Surface and intracellular distribution of a putative neuronal nicotinic acetylcholine receptor. J. Cell Biol. 103: 205–214.
- 63 Jacob , M. & D. Berg. 1983. The ultrastructural localization of α-bungarotoxin binding sites in relation to synapses on chick ciliary ganglion neurons. J. Neurosci. 3: 260–271.
- 64 Conti-Tronconi, B., S. Dunn, E. Barnard, J. Dolly, F. Lai, N. Ray & M. Raftery. 1985. Brain and muscle nicotinic acetylcholine receptors are different hut homologous proteins. Proc. Natl. Acad. Sci. USA 82: 5208–5212.
- 65 Séguéla, P., J. Wadiche, K. Dinelly-Miller, J. Dani & J. Patrick. 1993. Molecular cloning, functional properties, and distribution of rat brain α7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13: 596–604.
- 66 Peng , X., M. Katz, V. Gerzanich, R. Anand & J. Lindstrom. 1994. Human α7 acetylcholine receptor: Cloning of the α7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional α7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45: 546–554.
- 67 Mc Lane, K., X. Wu, J. Lindstrom & B. Conti-Tronconi. 1992. Epitope mapping of polyclonal and monoclonal antibodies against two α-bungarotoxin binding subunits from neuronal nicotinic receptors. J. Neuroimmunol. 38: 115–128.
- 68 Mc Lane, K., X. Wu, R. Schoepfer, J. Lindstrom & B. Conti-Tronconi. 1991. Identification of sequence segments forming the α-bungarotoxin binding sites on two nicotinic acetylcholine receptor α subunits from the avian brain. J. Biol. Chem. 266: 15230–15239.
- 69 Keyser , K., L. Britto, R. Schoepfer, P. Whiting, J. Cooper, W. Conroy, A. Brozozowska-Prechti. H. Karten & J. Lindstrom. 1993. Three subtypes of α-bungarotoxin sensitive nicotinic acetylcholine receptors are expressed in chick retina. J. Neurosci. 13: 442–454.
- 70 Gotti , C., A. Ogando, W. Hanke, R. Schule, M. Moretti & F. Clementi. 1991. Purification and characterization of an α-bungarotoxin receptor that forms a functional nicotinic channel. Proc. Natl. Acad. Sci. USA 88: 3258–3262.
- 71 Gotti , C., M. Moretti, R. Longhi, L. Briscini, E. Manura & F. Clementi. 1993. Antipeptide specific antibodies for the characterization of different a subunits of α-bungarotoxin binding acetylcholine receptors present in chick optic lobe. J. Recept. Res. 13: 453–465.
- 72 Courturier , S., D. Bertrand, J. Matter, M. Hernandez, S. Bertrand, N. Millar, S. Valera, T. Barkas & M. Ballivet. 1990. A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homomeric channel blocked by α-bungarotoxin. Neuron 5: 847–856.
- 73 Anand , R., X. Peng, J. Ballesta & J. Lindstrom. 1993. Pharmacological characterization of α-bungarotoxin sensitive AChRs immunoisolated from chick retina: Contrasting properties of α7 and α8 subunit-containing subtypes. Mol. Pharmacol. 44: 1046–1050.
- 74 Conroy , W., M. Saedi & J. Lindstrom. 1990. TE671 cells express an abundance of a partially mature acetylcholine receptor α subunit which has characteristics of an assembly intermediate. J. Biol. Chem. 265: 21642–21651.
- 75 Whiting , P. & J. Lindstrom. 1986. Pharmacological properties of immunoisolated neuronal nicotinic receptors. J. Neurosci. 6: 3061–3069.
- 76 Jackson , M. 1989. Perfection of a synaptic receptor: Kinetics and energetics of the acetylcholine receptor. Proc. Natl. Acad. Sci. USA 86: 2199–2203.
- 77 Galzi , J., A. Devillers-Thiery, N. Hussy, S. Bertrand, J. Changeux & D. Bertrand. 1992. Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359: 500–505.
- 78 Eisile , J., S. Bertrand, J. Galzi, A. Devillers-Thiery, J. Changeux & D. Bertrand. 1993. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature 366: 479–409.
- 79 Gerzanich , V., R. Anand & J. Lindstrom. 1994. Homomers of α8 subunits of nicotinic receptors functionally expressed in Xenoprrs oocytes exhibit similar channel but contrasting binding site properties compared to α7 homomers. Mol. Pharmacol. 45: 212–220.
- 80 Anand , R., X. Peng & J. Lindstrom. 1993. Homomeric and native α7 acetylcholine receptors exhibit remarkably similar but nonidentical pharmacological properties suggesting that the native receptor is a heteromeric protein complex. FEBS Lett. 327: 241–246.
- 81 Anand , R. & J. Lindstrom. Unpublished results.
- 82 Vernino , S., M. Amador, C. Luetje, J. Patrick & J. Dani. 1992. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8: 127–134.
- 83 Lipton , S., M. Frosh, M. Phillips, D. Tauck & E. Aizenman. 1988. Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture. Science 239: 1293–1296.
- 84 Zhang , Z., S. Vijayaroghaven & D. Berg. 1994. Neuronal acetylcholine receotors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 12: 167–177.
- 85 Pugh , P. & D. Berg, 1994. Neuronal acetylcholine receptors that bind α-bungarotoxin mediate neurite retraction in a calcium-dependent manner. J. Neurosci. 14: 889–896.
- 86 Alkondon , M. & E. Albuquerque. 1991. Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons. J. Recept. Res. 11: 1101–1201.
- 87 Alkondon , M. & E. Albuquerque. 1993. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265: 1455–1473.
- 88 Castro , N. & E. Albuquerque. 1993. Brief-lifetime, fast-inactivating ion channels account for the α-bungarotoxin-sensitive nicotinic response in hippocampal neurons. Neurosci. Lett. 164: 137–140.
- 89 Dei Toro, J. Juiz, X. Peng, J. Lindstrom & M. Criado. 1994. Immunocytochemical localization of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. J. Comp. Neurol. 349: 325–342.
- 90 Hamassaki-Britto, D., A. Brzozowska-Prechtl, H. Karen, J. Lindsikom & K. Keyser. 1991. GABA-like immunoreactive cells containing nicotinic acetylcholine receptors in the chick retina. J. Comp. Neurol. 313: 394–408.
- 91 Hamassaki-Britto, D., A. Brzozowska-Prechthl, H. Karten & J. Lindstrom. 1994. Bipolar cells of the chick retina containing α-bungarotoxin-sensitivc nicotinic acetylcholine receptors. Visual Neurosci. 11: 63–70.
- 92 Hamassaki-Britto, D., P. Gardino, J. Hokoc, K. Keyser, H. Karten, J. Lindstrom & L. Britto. 1994. Differential development of α-bungarotoxin-sensitive and α-bungarotoxin-insensitive nicotinic acetylcholine receptors in the chick retina. J. Comp. Neurol. 347: 161–170.
- 93 Fuchs , P. & B. Murrow. 1992. Cholinergic inhibition of short (outer) hair cells of the chick's cochlea. J. Neurosci. 12: 800–809.
- 94 Fuchs , P. & B. Murrow. 1992. A novel cholinergic receptor mediates inhibition of chick cochlear hair cells. Proc. R. Soc. Lond. B. 248: 35–40.
- 95 Anand , R., V. Gerzanich, J. Cooper, X. Pfng, P. Fuchs & J. Lindstrom. Unpublished results.
- 96 Elgoyhen , A., D. Johnson, J. Boulter, D. Vetter & S. Heinemann. 1994. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79: 705–715.
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