Development of the Mouse B-Cell Repertoirea
FLAVIUS MARTIN,
XINJIAN CHEN,
FENGYU SHU,
JOHN F. KEARNEY,
FLAVIUS MARTIN
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorXINJIAN CHEN
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorFENGYU SHU
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorCorresponding Author
JOHN F. KEARNEY
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Address for correspondence: John F. Kearney, 378 WTI, University of Alabama at Birmingham, Birmingham, Alabama 35294-3300.Search for more papers by this authorFLAVIUS MARTIN,
XINJIAN CHEN,
FENGYU SHU,
JOHN F. KEARNEY,
FLAVIUS MARTIN
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorXINJIAN CHEN
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorFENGYU SHU
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Search for more papers by this authorCorresponding Author
JOHN F. KEARNEY
Division of Developmental and Clinical Immunology Department of Microbiology University of Alabama at Birmingham Birmingham, Alabama 35294
Address for correspondence: John F. Kearney, 378 WTI, University of Alabama at Birmingham, Birmingham, Alabama 35294-3300.Search for more papers by this authora
This work was supported in part by National Institutes of Health Grants Al 14782, Al 30879, and CA 13148.
REFERENCES
- 1 Cumano, A., C. Furlonger & C. G. Paige. 1993. Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage. Proc. Natl. Acad. Sci. USA 90: 6429–6433.
- 2 Godin, I. E., J. A. Garcia-Porrero, A. Coutinho, F. Dieterlen-lievre & M. Marcos. 1993. Para-aortic splanchnopleura from early mouse embryos contain Bla cell progenitors. Nature 364: 67–70.
- 3 Palacios, R. & B. A. Imhof. 1993. At day 8–8.5 of mouse development the yolk sac, not the embryo proper, has lymphoid precursor potential in vivo and in vitro. Proc. Natl. Acad. Sci. USA 90: 6581–6585.
- 4 Solvason, N., A. Lehuen & J. F. Kearney. 1991. An embryonic source of Lyl but not conventional B cells. Intl. Immunol. 3: 543–550.
- 5 Rolink, A. & F. Melchers. 1991. Molecular and cellular origins of B lymphocyte diversity. Cell 66: 1081.
- 6 Rolink, A. & F. Melchers. 1993. Blymphopoiesis in the mouse, Adv. Immun. 53: 123–155.
- 7 Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp & K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213.
- 8 Kincade, P. W. 1991. Molecular interactions between stromal cells and B lymphocyte precursors. Semin. Immunol. 3: 379–390.
- 9 Li, Y-S., K. Hayakawa & R. R. Hardy, 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178: 951–960.
- 10 Kearney, J. F., M. D. Cooper, J. Klein, E. R. Abney, R. M. E. Parkhouse & A. R. Lawton. 1977. Ontogeny of Ia and IgD on IgM—bearing B lymphocytes in mice. J. Exp. Med. 146: 297–302.
- 11 Hayakawa, K., D. Tarlinton & R. R. Hardy. 1994. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J. Immunol. 152: 4801–4807.
- 12 Lam, K.-P. & A. M. Stall. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180: 507–511.
- 13 Oltz, E. M., G. D. Yancopoulos, M. A. Morrow, A. Rolink, G. Lee, F. Wong, K. Kaplan, S. Gillis, F. Melchers & F. W. Alt. 1992. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J. 11: 2759–2767.
- 14 Rolink, A., D. Haasner, S.-I. Nishikawa & F. Melchers. 1993. Changes in frequencies of clonable pre-B cells during life in different lymphoid organs in mice. Blood 81: 2290–2300.
- 15 Hamilton, A. M., A. Lehuen & J. F. Kearney. 1994. Immunofluorescence analysis of B-1 B cell ontogeny in the mouse. Int. Immunol. 6: 355–361.
- 16 Yancopoulos, G. D., S. V. Desiderio, M. Paskind, J. F. Kearney, D. Baltimore & F. W. Alt. 1984. Preferential utilization of the most JH-proximal VH gene segments in pre-B cell lines. Nature 311: 727–733.
- 17
Carlsson, L. &
D. Holmberg. 1990. Genetic basis of the neonatal antibody repertoire: Germline V-gene expression and limited N region diversity.
Int. Immunol. 3: 639–643.
10.1093/intimm/2.7.639 Google Scholar
- 18 Feeney, A. J. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172: 1377–1390.
- 19 Medina, C. A. & J. M. Teale. 1993. Restricted k chain expression in early ontogeny: Biased utilization of Vk exons and preferential Vk-Jk recombinations. J. Exp. Med. 177: 1313–1330.
- 20 Kearney, J. F., J. Bartels, A. M. Hamilton, A. Lehuen, N. Solvason & M. Vakil. 1992. Development and function of the early B cell repertoire. Int. Rev. Immunol. 8: 247–257.
- 21 Hartley, S. B. J., Crosbie, R. Brink, A. B. Kantor, A. Basten & C.C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature (London) 353: 765.
- 22 Goodnow, C. C., J. Crosbie, H. Jorgensen, R. A. Brink & A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342: 385–391.
- 23 Tiegs, S. L., D. M. Russell & D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177: 1009–1020, 1993.
- 24 Gay, D., T. Saunders, S. Camper & M. Weigert. 1993. Receptor editing: An approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177: 999–1008.
- 25 Cyster, J. G., S. B. Hartley & C. C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371: 389–395.
- 26 Gu, H., I. Forster & K. Rajewsky. 1990. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and C-CLL progenitor generation. EMBO J. 9: 2133–2140.
- 27 Gu, H., D. Tarlinton, W. Muller, K. Rajewsky & I. Foster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173: 1357–1371.
- 28 Pandey, A., L. W. Tjoelker & C. B. Thompson. 1993. Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joining. J. Exp. Med. 177: 329–337.
- 29 Kenny, J. J., C. O'Connel, D. G. Sieckmann, R. T. Fisher & D. L. Longo. 1991. Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167-μ heavy chain gene. J. Exp. Med. 174: 1189–1201.
- 30 Arnold, L. W., C. A. Pennell, S. K. Mccray & S. H. Clarke. 1994. Development of B-1 cells: Segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179: 1585–1595.
- 31 Hayakawa, K., C. E. Carmack, S. A. Shinton & R. R. Hardy. 1992. Selection of autoantibody specificities in the Ly-1 B subset. Ann. N.Y. Acad. Sci. 651: 346.
- 32 Spanopoulou, E., C. A. Roman, L. M. Corcoran, M. S. Schlissel, D. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy & D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in rag-1–deficient mice. Genes Dev. 8: 1030–1042.
- 33 Young, F., B. Ardman, Y. Shinkai, R. Lansford, T. K. Blackwell, M. Mendelsohn, A. Rolink, F. Melchers & F. W. Alt. 1994. Influence of immunoglobulin heavy and light-chain expression on B-cell differentiation. Genes Dev. 8: 1043–1057.
- 34 Lundkvist, I., A. Coutinho, F. Varela & D. Holmberg. 1989. Evidence for a functional idiotypic network among natural antibodies in normal mice. Proc. Natl. Acad. Sci. USA 86: 5074–5078.
- 35 Haury, M., A. Grandien, A. Sundblad, A. Coutinho & A. Nobrega. 1994. Global analysis of antibody repertoires. I. An immunoblot method for quantitative screening of a large number of reactivities. Scand. J. Immunol. 39: 79–87.
- 36 Nobrega, A., M. Haury, A. Grandien, E. Malanchere, A. Sundblad & A. Coutinho. 1993. Global analysis of antibody repertoires. II. Evidence for specificity, self-selection and the immunological “homunculus” of antibodies in normal serum. Eur. J. Immunol. 23: 2851–2859.
- 37 Winter, G., A. D. Griffiths, R. E. Hawkins & H. R. Hoogenboom. 1994. Making antibodies by phage display technology. Ann. Rev. Immunol. 12: 433–445.
- 38 Holmberg, D., S. Forsgren, F. IVARS & A. Coutinho. 1984. Reactions amongst IgM antibodies isolated from the early B cell repertoire of BALB/c mice. Eur. J. Immunol. 14: 435–442.
- 39 Elliott, M. & J. F. Kearney. 1992. Idiotypic regulation of development of the B cell repertoire. Ann. N.Y. Acad. Sci. 651: 336–345.
- 40 Kearney, J. F. 1993. Idiotypic networks. In Fundamental Immunology. Vol. 3. W. E. Paul, Ed.: 887–902. Raven Press. New York .
- 41 Avrameas, S. & T. Ternynck. 1993. The natural autoantibodies system: Between hypotheses and facts. Mol. Immunol. 30: 1133–1142.
- 42 Malynn, B. A., G. D. Yancopoulos, J. E. Barth, C. A. Bona & F. W. Alt. 1990. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J. Exp. Med. 171: 843–859.
- 43 Carlsson, L., C. Overmo & D. Holmberg. 1992. Selection against N-region diversity in immunoglobulin heavy chain variable regions during the development of preimmune B cell repertoires. Int. Immunol. 4: 549–553.
- 44 Chang, Y., C. J. Paige & G. Wu. 1992. Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J. 11: 1891–1899.
- 45 Huetz, F., L. Carlsson, U.-C. Tornberg & D. Holmberg. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12: 1819–1826.
- 46 Teale, J. M. & C. A. Medina. 1992. Comparative expression of adult and fetal V gene repertoires. Int. Rev. Immunol. 8: 95–111.
- 47 Ternynck, T. & S. Avrameas. 1986. Murine natural monoclonal autoantibodies: A study of their polyspecificities and their affinities. Immun. Rev. 94: 98–112.
- 48 Ichiyoshi, Y. & P. Casali. 1994. Analysis of the structural correlates for antibody oligoreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. J. Exp. Med. 180: 885–895.
- 49 Holmberg, D., G. Wennerstrom, L. Andrade & A. Coutinho. 1986. The high idiotypic connectivity of “natural” newborn antibodies is not found in adult mitogen-reactive B cell repertoires. Eur. J. Immunol. 16: 82–87.
- 50 Shefner, R., G. Kleiner, A. Turken, L. Papazian & B. Diamond. 1991. A novel class of anti-DNA antibodies identified in BALB/c mice. J. Exp. Med. 173: 287–296.
- 51 Chen, C., V. A. Roberts & M. B. Rittenberg. 1992. Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen. J. Exp. Med. 176: 855–866.
- 52 Lehuen, A., J. Bartels & J. F. Kearney. 1992. Characterization, specificity and Ig V gene usage of anti-lymphocyte monoclonal antibodies from perinatal mice. Int. Immunol. 4: 1073–1084.
- 53 Kearney, J. F. 1992. Early B cell repertoire. In Current Topics in Microbiology and Immunology. Springer-Verlag. Berlin , pp. 81–84.
- 54 Mccormack, W. T., L. W. Tjoelker, C. F. Barth, L. M. Carlson, B. Petryniak, E. H. Humphries & C. B. Thompson. 1989. Selection for B cells with productive IgL gene rearrangements occurs in the bursa of Fabritius during chicken embryonic development. Genes Dev. 3: 838–847.
- 55 Reynaud, C.-A., C. R. Mackay, R. G. Muller & J.-C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches. Cell 64: 995–1005.
- 56 Chen, X. & J. F. Kearney. Positive selection of spontaneous auto-reactive B cells. Submitted.
