Long-term Health Effects of the Occupational Exposure to DDT
A Preliminary Report†
Corresponding Author
PIERLUIGI COCCO
Istituto di Medicina del Lavoro Universita di Cagliari Cagliari, Italy
Address for correspondence and reprint requests: Pierluigi Cocco, M.D., Institute of Occupational Medicine, University of Cagliari, via San Giorgio 12, 09126 Cagliari, Italy. Phone: + 39 70 602-8278; fax: + 39 70 654350; e-mail: [email protected]Search for more papers by this authorAARON BLAIR
Occupational Studies Section Environmental Epidemiology Branch National Cancer Institute Bethesda, Maryland 20892
Search for more papers by this authorPATRIZIA CONGIA
Istituto di Medicina del Lavoro Universita di Cagliari Cagliari, Italy
Search for more papers by this authorGIOVANNA SABA
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorANNA R. ECCA
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorCOSTANTINO PALMAS
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorCorresponding Author
PIERLUIGI COCCO
Istituto di Medicina del Lavoro Universita di Cagliari Cagliari, Italy
Address for correspondence and reprint requests: Pierluigi Cocco, M.D., Institute of Occupational Medicine, University of Cagliari, via San Giorgio 12, 09126 Cagliari, Italy. Phone: + 39 70 602-8278; fax: + 39 70 654350; e-mail: [email protected]Search for more papers by this authorAARON BLAIR
Occupational Studies Section Environmental Epidemiology Branch National Cancer Institute Bethesda, Maryland 20892
Search for more papers by this authorPATRIZIA CONGIA
Istituto di Medicina del Lavoro Universita di Cagliari Cagliari, Italy
Search for more papers by this authorGIOVANNA SABA
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorANNA R. ECCA
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorCOSTANTINO PALMAS
Istituto di Parassitologia Università. di Cagliari Cagliari, Italy
Search for more papers by this authorThe work of one of the authors (P.C.) at the National Cancer Institute was supported with funding from the International Union Against Cancer (Geneva, Switzerland) and the NCI/EORTC Exchange Program (Brussels, Belgium).

REFERENCES
- 1
International Agencyfor Researchon Cancer. 1991. IARC Monographs for the Evaluation of Carcinogenic Risk of Chemicals to Humans, Vol. 53, Occupational Exposures in Insecticide Application, and Some Pesticides: 179–249. IARC.
Lyon
.
- 2
Austin, H.,
I. E. Keil &
P. Cole
1989. A prospective follow-up study of cancer mortality in relation to serum DDT.
Am. J. Public Health
79: 43–46.
- 3
Brown, L. M.,
A. Blair,
R. Gibson, et al.
1990. Pesticide exposure and other agricultural risk factors for leukemia among men in Iowa and Minnesota.
Cancer
50: 1685–1691.
- 4
Ditraglia, D.,
D. P. Brown,
T. Namekata &
N. Iverson
1981. Mortality study of workers employed at organochlorine pesticide manufacturing plants.
Scand. J. Work Environ. Health
7(Suppl. 4): 140–146.
- 5
Flodin, U.,
M. Fredriksson,
B. Persson &
O. Axelson
1988. Chronic lymphatic leukaemia and engine exhausts, fresh wood, and DDT: A case-referent study.
Br. J. Ind. Med.
45: 33–38.
- 6
Garabrant, D. H.,
J. Held,
B. Langholz,
J. M. Peters &
T. M. Mack
1992. DDT and related compounds and risk of pancreatic cancer.
J. Natl. Cancer Inst.
84: 764–771.
- 7
Wong, O.,
W. Brocker,
H. V. Davis &
G. Sn
1984. Mortality of workers potentially exposed to organic and inorganic brominated chemicals, DBCP, Tris, PBB and DDT.
Br. J. Ind. Med.
41: 15–24.
- 8
Woods, J. S.,
L. Polissar,
R. K. Severson,
L. S. Heuser &
B. G. Kulander
1987. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in Western Washington.
J. Natl. Cancer Inst.
78: 899–910.
- 9
Wolff, M. S.,
P. G. Toniolo,
E. W. Lee,
M. Rivera &
N. Dubin
1993. Blood levels of organochlorine residues and risk of breast cancer.
J. Natl. Cancer Inst.
85: 648–652.
- 10
Falck, F., Jr., A. Ricci, Jr., M. S. Wolff,
J. Godbold &
P. Deckers
1992. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer.
Arch. Environ. Health
47: 143–146.
- 11
Krieger, N.,
M. S. Wolff,
R. A. Hiatt,
M. Rivera,
J. Vogelman &
N. Orentreich
1994. Breast cancer and serum organochlorines: A prospective study among white, black, and Asian women.
J. Natl. Cancer Inst.
86: 589–599.
- 12
Logan, J. A.
1953. The Sardinian Project: An Experiment in the Eradication of an Indigenous Malarious Vector. The Johns Hopkins Press.
Baltimore
,
MD
.
- 13
International Classificationof Diseases. 1977.1975 revision, World Health Organization.
Geneva
.
- 14
Liddell, F. D. K.
1984. Simple exact analysis of the Standardized Mortality Ratio.
J. Epidemiol. Community Health
38: 85–88.
- 15
FAO/WHO. 1985. Pesticide residues in food-1984. Report of the Joint Meeting on Pesticide Residues, FAO Plant Production and Protection,
Rome
.
- 16
Mes, J.,
D. J. Davies &
D. Turton
1982. Polychlorinated biphenyl and other chlorinated hydrocarbon residues in adipose tissue of Canadians.
Bull. Environ. Contam. Toxicol.
28: 97–104.
- 17
Jani, J. P.,
I. S. Patel,
M. P. Shah, et al.
1988. Levels of dichloro-diphenyl-trichloroethane and hexachlorocyclohexane in human adipose tissue of the Indian population.
Scand. J. Work Environ. Health
14: 201–204.
- 18
Mes, J.,
L. Marchand &
D. J. Davies
1990. Organochlorine residues in adipose tissue of Canadians.
Bull. Environ. Contam. Toxicol.
45: 681–688.
- 19
Burgaz, S.,
L. Afkham &
A. E. Karakaya
1994. Organochlorine pesticide contaminants in human adipose tissue collected in Ankara (Turkey) 1991-92.
Bull. Environ. Contam. Toxicol.
53: 50–58.
- 20
Kreiss, K.,
M. M. Zack,
R. D. Kimbrough,
L. L. Needham,
A. L. Smrek &
B. T. Jones
1981. Cross-sectional study of a community with exceptional exposure to DDT.
JAMA
245: 1926–1930.
- 21
Hovinga, M. E.,
M. Sowers &
H. E. Bh
1993. Environmental exposure and lifestyle predictors of lead, cadmium, PCB, and DDT levels in Great Lakes fish eaters.
Arch. Environ. Health
48: 98–104.
- 22
Asplund, L.,
B.-G. Svensson,
A. Nilsson, et al.
1994. Polychlorinated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT) and l,l-dichloro-2,2-bis(p-chloro-phenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption.
Arch. Environ. Health
49: 477–486.
- 23
Kashyan, R.,
L. R. Iyer &
M. M. Singh
1994. Evaluation of daily dietary intake of dichloro-diphenyl-trichloroethane (DDT) and benzene hexachloride (BHC) in India.
Arch. Environ. Health
49: 63–66.
- 24
Wassermann, M.,
D. P. Nogueira,
L. Tomatis, et al.
1976. Organochlorine compounds in neoplastic and adjacent apparently normal breast tissue.
Bull. Environ. Contam. Toxicol.
15: 478–484.
- 25
Unger, M. &
J. Olsen
1980. Organochlorine compounds in the adipose tissue of deceased people with and without cancer.
Environ. Res.
23: 257–263.
- 26
Saxena, S. P.,
C. Khare,
A. Farooq,
K. Murugesan,
K. Buckshee &
J. Chandra. 1987. DDT and its metabolites in leiomyomatous and normal human uterine tissue.
Arch. Toxicol.
59: 453–455.
- 27
Capocaccia, R.,
G. Farchi,
S. Mariotti, et al.
1989. La mortalita
in
Italia nell'anno
1985. Istituto Superiore di Sanita.
Roma
. (ISTISAN 89/6).
- 28
Deichmann, W. B. &
W. E. MacDonald
1977. Organochlorine pesticides and liver cancer deaths in the United States, 1930-1972.
Ecotoxicol. Environ. Saf.
1: 89–110.
- 29
Brown, L. M.,
L. F. Burmeister,
G. D. Everett &
A. Blair
1993. Pesticide exposures and multiple myeloma in Iowa men.
Cancer Causes Control
4: 153–156.
- 30
Cantor, K. P.,
A. Blair,
G. Everett, et al.
1992. Pesticides and other agricultural risk factors for non-Hodgkin's lymphoma among men in Iowa and Minnesota.
Cancer Res.
52: 2447–2455.
- 31
Pearce, N. E.,
A. H. Smith &
D. O. Fisher
1985. Malignant lymphoma and multiple myeloma linked with agricultural occupations in a New Zealand Cancer Registry-based study.
Am. J. Epidemiol.
121: 225–237.
- 32
Corrao, G.,
M. Calleri,
F. Carle,
R. Russo,
S. Bosia &
P. Piccioni
1989. Cancer risk in a cohort of licensed pesticide users.
Scand. J. Work Environ. Health
15: 203–209.
- 33
Wiklund, K.,
J. Dich,
L.-E. Holm &
G. Eklund
1989. Risk of cancer in pesticide applicators in Swedish agriculture.
Br. J. Ind. Med.
46: 809–814.
- 34
Stottrup Hansen, E.,
H. Hasle &
F. Lander
1992. A cohort study on cancer incidence among Danish gardeners.
Am. J. Ind. Med.
21: 651–660.
- 35
Faustini, A.,
F. Forastiere,
L. Di Betta,
E. M. Magliola &
C. Ap
1994. Cohort study of mortality among farmers and agricultural workers.
Med. Lav.
84: 31–41.