Regulation of Inhibitory Pathways of the Interleukin-1 System
A. MANTOVANI,
M. MUZIO,
P. GHEZZI,
C. COLOTTA,
M. INTRONA,
A. MANTOVANI
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorM. MUZIO
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorP. GHEZZI
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorC. COLOTTA
Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Milan, Italy
Search for more papers by this authorM. INTRONA
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorA. MANTOVANI,
M. MUZIO,
P. GHEZZI,
C. COLOTTA,
M. INTRONA,
A. MANTOVANI
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorM. MUZIO
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorP. GHEZZI
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorC. COLOTTA
Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Milan, Italy
Search for more papers by this authorM. INTRONA
Istituto di Ricerche Farmacologiche “Mario Negrirdquo;, via Eritrea 62,20157 Milano, Italy and (AM) Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Search for more papers by this authorAddress for correspondence: Istituto di Ricerche Farmacologiche “Mario Negri” via Eritrea 62, 20157 Milano, Italy.
Abstract
Abstract: The IL-1 system includes two agonists, converting enzymes, antagonists, and two receptors (R). New elements and functions in the system will be discussed, including (a) cloning of a new isoform of the receptor antagonist; (b) further analysis of the type II IL-1-binding molecule as a decoy R. The modulation of IL-1R by chemotactic signals was recently investigated. It was found that chemoattractants cause rapid release of the type II decoy R from myelomonocytic cells with a t1/2 of 30 sec. Induction of decoy R release represents an early event in the multistep process of recruitment. It may serve to block the systemic action of IL-1 leaking from sites of inflammation, while preserving responsiveness in situ. We recently cloned the first long pentraxin, PTX3 (human and mouse, cDNA and genomic) as an IL-1-inducible gene. The structural and functional features of this molecule as well as initial evidence of involvement in human pathology will be discussed.
REFERENCES
- 1 Dinarello, C. A., 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627–1652.
- 2 Dinarello, C. A., 1994. Blocking interleukin-1 receptors. Int. J. Clin. Lab. Res. 24: 61–79.
- 3 Oppenheim, J. J. & I. Gery. 1993. From lymphodrek to interleukin 1 (IL-1). Immunol. Today. 1993. 14: 232–234.
- 4 Colotta, F., S. K. Dower, J. E. Sims & A. Martovani. 1994. The type II ‘decoy’ receptor: Novel regulatory pathway for interleukin-1. Immunol. Today. 156: 562–566.
- 5 Arend, W. P., 1993. Interleukin-1 receptor antagonist. Adv. Immunol. 54: 167–227.
- 6 Bagby, G. C. J. 1989. Interleukin-1 and hematopoiesis. Blood Rev. 3: 152–161.
- 7 Fibbe, W. E., J. W. van der Meer, J. H. Falkenberg, M. S. Hamilton, P. M. Kluin & C. A. Dinarello. 1989. A single low dose of human recombinant interleukin 1 accelerates the recovery of neutrophils in mice with cyclophosphamide-induced neutropenia. Exp. Hematol. 17: 805–808.
- 8 Neta, R., J. J. Oppenheim & S. D. Douches. 1988. Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. 140: 108–111.
- 9 Oppenheim, J. J., R. Neta, P. Tiberghien, R. Gress, J. J. Kenny & D. L. Longo. 1989. Interleukin-1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells. Blood 74: 2257–2263.
- 10 Muegge, K., T. M. Williams, J. Kant, M. Karin, R. Chiu, A. Schmidt, U. Siebenlist, H. A. Young & S. K. Durum. 1989. Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP- 1. Science 246: 249–251.
- 11 Manetti, R., V. Barak, M. P. Piccinni, S. Sampognaro, P. Parronchi, E. Maggi, C. A. Dinarello & S. Romagnani. 1994. Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones. Res. Immunol. 145: 93–100.
- 12 Colotta, F., F. Re, N. Polentarutti, S. Sozzani & A. Mantovani. 1992. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80: 2012–2020.
- 13 Bevilacqua, M. P., J. S. Pober, G. R. Majeau, R. S. Cotran & M. A. Gimbrone, Jr. 1984. Interleukin-1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J. Exp. Med. 160: 618–623.
- 14 Dejana, E., F. Breviario, G. Balconi, V. Rossi, G. Remuzzi, G. De Gaetano & A. Mantovani. 1984. Stimulation of prostacyclin synthesis in vascular cells by mononuclear cell products. Blood 64: 1280–1283.
- 15 Rossi, E., F. Breviario, E. Dejana & A. Mantovani. 1985. Prostacyclin synthesis induced in vascular cells by interleukin-1. Science 229: 174–176.
- 16 Mantovani, A., F. Bussolino & E. Dejana. 1992. Cytokine regulation of endothelial cell function. FASEB. J. 6: 2591–2599.
- 17 Basedovsky, H., A. del Rey & C. A. Dinarello. 1986. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233: 652–654.
- 18 Sapolsky R., C. Rivier, G. Yamamoto, P. Plotsky & W. Vale. 1987. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238: 522–524.
- 19 Woloski, B. M. R. N. J., E. M. Smith, W. J. I. Meyer, G. M. Fuller & J. E. Blalock. 1985. Corticotropin-releasing activity of monokines. Science 230: 1035–1037.
- 20 Fantuzzi, G. & P. Ghezzi. 1993. Glucocorticoids as cytokine inhibitors: Role in neuroendocrine control and therapy of inflammatory diseases. Mediat. Inflamm. 2: 263–270.
- 21 Bertini, R., M. Bianchi & P. Ghezzi. 1988. Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exp. Med. 167: 1708–1712.
- 22 Dinarello, C. A., 1984. Interleukin-1 and the pathogenesis of the acute-phase response. N. Engl. J. Med. 311: 1413–1418.
- 23 Kampschmidt, R. F. & L. A. Pulliam. 1978. Effect of human monocyte pyrogen on plasma iron, plasma zinc, and blood neutrophils in rabbits and rats. Proc. Soc. Exp. Biol. Med. 158: 32–35.
- 24 Kampschmidt, R. F., L. A. Pulliam & H. F. Upchurch. 1980. The activity of partially purified leukocytic endogenous mediator in endotoxin-resistant C3H/HeJ mice. J. Lab. Clin. Med. 95: 616–623.
- 25 VanSnick, J., P. L. Masson & J. F. Heremans. 1974. The involvement of lactoferrin in the hyposideremia of acute inflammation. J. Exp. Med. 140: 1068–1084.
- 26 Kushner, I. 1982. The phenomenon of the acute-phase response. Ann. N.Y. Acad. Sci. USA 389: 39–48.
- 27 Ramadori, G., J. D. Sipe, C. A. Dinarello, S. B. Mizel & H. R. Colten. 1985. Pretranslational modulation of acute-phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J. Exp. Med. 162: 930–942.
- 28 Heinrich, P. C., J. V. Castell & T. Andus. 1990. Interleukin 6 and the acute-phase response. Biochem. J. 265: 621–636.
- 29 Atkins, E. & W. B. J. Wood. 1955. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the bloodstream following the injection of typhoid vaccine. J. Exp. Med. 102: 499–516.
- 30 Dinarello, C. A., L. Renfer & S. M. Wolff. 1977. Human leukocytic pyrogen: Purification and development of a radioimmunoassay. Proc. Natl. Acad. Sci. USA. 74: 4624–4627.
- 31 Dinarello, C. A., J. G. Cannon, J. W. Mier, H. A. Bernheim, G. LoPreste, D. L. Lynn, R. N. Love, A. C. Webb, P. E. Auron, R. C. Reuben, A. Rich, S. M. Wolff & S. D. Putney. 1986. Multiple biological activities of human recombinant interleukin 1. J. Clin. Invest. 77: 1734–1739.
- 32 Dinarello, C. A., J. G. Cannon, S. M. Wolff, H. A. Bernheim, B. Beutler & A. Cerami. 1986. Tumor necrosis factor (cachectin) is an andogenous pyrogen and induces production of interleukin 1. J. Exp. Med. 163: 1433–1450.
- 33 Dinarello C. A., J. G. Cannon, J. Mancilla, I. Bishai, J. Lees & F. Coceani. 1991. Interleukin-6 as an endogenous pyrogen: Induction of prostaglandin E2 in brain but not in peripheral blood mononuclear cells. Brain Res. 562: 199–206.
- 34 Rettori, V., M. F. Gimeno, A. Karara, M. C. Gonzalez & S. M. McCann. 1991. Interleukin 1α inhibits prostaglandin E2 release to suppress pulsatile release of luteinizing hormone but not follicle-stimulating hormone. Proc. Natl. Acad. Sci. USA. 88: 2763–2767.
- 35 Krueger, J. M., L. A. Toth, R. Floyd, J. Fang, L. Kapas, S. Bredow & J. F. Obal. 1994. Sleep, microbes and cytokines. Neuroimmunomodulation 1: 100–109.
- 36 Uehara, A., C. Sekiya, Y. Takasugi, M. Namiki & A. Arimura. 1990. Anorexia induced by interleukin-1: Involvement of corticotropin-releasing factor. Am. J. Physiol. 137: 1173–1185.
- 37 Hellerstein, M. K., S. N. Meydani, M. Meydani & C. A. Dinarello. 1989. Interleukin-1-induced anorexia in rat. J. Clin. Invest. 84: 228–235.
- 38 Dayer, J. M., B. de Rochemonteix, B. Burrus, S. Demczuk & C. A. Dinarello. 1986. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J. Clin. Invest. 77: 645–648.
- 39 Saklatvala, J., S. J. Sarsfield & Y. Townsend. 1985. PIG Interleukin-1. J. Exp. Med. 162: 1208–1222.
- 40 Schmidt, J. A., S. B. Mizel, D. Cohen & I. Green. 1989. Interleukin 1, a potential regulator of fobroblast proliferation. J. Immunol. 128: 2177–2182.
- 41 Postlethwaite, A. E., L. B. Lachman, C. L. Mainardi & A. H. Kang. 1983. Interleukin 1 stimulation of collagenase production by cultured fibroblasts. J. Exp. Med. 157: 801–806.
- 42 Okusawa, S., J. A. Gelfand, T. Ikejima, R. J. Connolly & C. A. Dinarello. 1988. Interleukin I induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J. Clin. Invest. 81: 1162–1172.
- 43 Bendtzen, K., T. Mandrup-Poulsen, J. Nerup, J. H. Nielsen, C. A. Dinarello & M. Svenson. 1986. Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans. Science 232: 1545–1547.
- 44 Haskill, S., G. Martin, L. Van Le, J. Morris, A. Peace, C. F. Bigler G. J. Jaffe, C. Hammerberg, S. A. Sporn, S. Fong et al. 1991. cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. Proc. Natl. Acad. Sci. USA. 88: 3681–3685.
- 45 Muzio, M., F. Re, M. Sironi, N. Polentarutti, A. Minty, D. Caput, P. Ferrara, A. Mantovani & F. Colotta. 1994. Interleukin-13 induces the production of interleukin-1 receptor antagonist (IL-1ra) and the expression of the mRNA for the intracellular (keratinocyte) form of IL-1ra in human myelomonocytic cells. Blood 83: 1738–1743.
- 46 Muzio, M., M. Sironi, N. Polentarutti, A. Mantovani & F. Colotta. 1994. Induction by transforming growth factor beta 1 (TGFbl) of the interleukin 1 receptor antagonist (IL-1ra) and of its intracellular form in human polymorphonuclear cells. Eur. J. Immunol. 24: 3196–3198.
- 47 Krzesicki, R. F., C. A. Hatfield, M. J. Bienkowski, J. C. McGuire, G. E. Winterrowd, D. L. Chapman, A. E. Berger, R. N. McEwan, D. B. Carter, J. G. Chosay et al. 1993. Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts. J. Immunol. 150: 4008–4018.
- 48 Steinkasserer, A., N. K. Spurr, S. Cox, P. Jeggo & R. B. Sim. 1992. The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics 13: 654–657.
- 49 Smith, M. F. J., D. Eidlen, M. T. Brewer, S. P. Eisenberg, W. P. Arend & A. Gutierrez Hartmann. 1992. Human IL-1 receptor antagonist promoter. Cell type-specific activity and identification of regulatory regions. J. Immunol. 149: 2000–2007.
- 50 Muzio, M., N. Polentarutti, M. Sironi, G. Poli, L. De Gioia, M. Introna, A. Mantovani & F. Colotta. 1995. Cloning and characterization of a new isoform of the interleukin-1 receptor antagonist. J. Exp. Med. 182: 623–628.
- 51 Re, F., Mengozzi M., M. Muzio, C. A Dinarello, A. Mantovani & F. Colotta. 1993. Expression of interleukin-1 receptor antagonist (IL-1ra) by human circulating polymorphonuclear cells. Eur. J. Immunol. 23: 570–573.
- 52 Cassatella, M. A., L. Meda, S. Gasperini, F. Calzetti & S. Bonora. 1994. Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J. Exp. Med. 179: 1695–1699.
- 53 Sims, J. E., C. J. March, D. Cosman, M. B. Widmer, H. R. Mac Donald, C. J. McMahan, C. E. Grubin, J. M. Wignall, J. L. Jackson, S. M. Call, D. Friend, A. R. Alpert, S. Gillis, D. L. Urdal & S. K. Dower. 1988. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241: 585–589.
- 54 Sims, J. E., R. B. Acres, C. E. Grubin, J. McMahan, J. M. Wignall, C. J. March & S. K. Dower. 1989. Cloning of the interleukin 1 receptor from human T cells. Proc. Natl. Acad. Sci. USA. 86: 8946–8950.
- 55 McMahan, C. J., J. L. Slack, B. Mosley, D. Cosman, S. D. Lupton, L. L. Brunton, C. E. Grubin, J. M. Wignall, N. A. Jenkins, C. I. Brannan et al. 1991. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10: 2821–2832.
- 56 Greenfeder, S. A., P. Nunes, L. Kwee, M. Labow, R. Chizzonite & G. Ju. 1995. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 270: 13757–13765.
- 57 Ye, K., C. A. Dinarello & B. D. Clark. 1993. Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression. Proc. Natl. Acad. Sci. USA. 90: 2295–2299.
- 58 Boraschi, D., A. Rambaldi, A. Sica, P. Ghiara, F. Colotta, J. M. Wang, M. De Rossi, C. Zoia, G. Remuzzi, F. Bussolino, S. Scapigliati, A. Stoppacciaro, L. Ruco, A.Tagliabue & A. Mantovani. 1991. Endothelial cells express the interleukin-1 receptor type I. Blood 78: 1262–1267.
- 59 Colotta, F., M. Sironi, A. Borre, T. Pollicino, S. Bernasconi, D. Boraschi & A. Mantovani. 1993. Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation. Blood 81: 1347–1351.
- 60 Sims, J. E., M. A. Gayle, J. L. Slack, M. R. Alderson, T. A. Bird, J. G. Giri, F. Colotta, F. Re, A. Mantovani, K. Shanebeck, K H. Grabstein & S. K. Dower. 1993. Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl. Acad. Sci. USA 90: 6155–6159.
- 61 McKean, D. J., R. P. Podzorski, M. P. Bell, A. E. Nilson, C. J. Huntoon, J. Slack, S. K. Dower & J. Sims. 1993. Murine T helper cell-2 lymphocytes express type I and type II IL-1 receptors, but only the type I receptor mediates costimulatory activity. J. Immunol. 151: 3500–3510.
- 62 Colotta, F., F. Re, M. Muzio, R. Bertini, N. Polentarutti, M. Sironi, J. G. Giri, S. K. Dower, J. E. Sims & A. Mantovani. 1993. Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261: 472–475.
- 63 Re, F., M. Muzio, M. De Rossi, N. Polentarutti, J. G. Giri, A. Mantovani & F. Colotta. 1994. The type II “receptor” as a decoy target for IL-1 in polymorphonuclear leukocytes: Characterization of induction by dexamethasone and ligand-binding properties of the released decoy receptor. J. Exp. Med. 179: 739–743.
- 64 Colotta, F., F. Re, M. Muzio, N. Polentarutti, A. Minty, D. Caput, P. Ferrara & A. Mantovani. 1994. IL-13 induces expression and release of the IL-1 decoy receptor in human polymorphonuclear cells. J. Biol. Chem. 269: 12403–12406.
- 65 Colotta F., S. Orlando, E. J. Fadlon, S. Sozzani, C. Matteucci & A. Mantovani. 1995. Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells. J. Exp. Med. 181: 2181–2188.
- 66 Alcami, A. & G. L. Smith. 1992. A soluble receptor for interleukin-1 beta encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection. Cell 71: 153–167.
- 67 Spriggs, M. K., D. E. Hruby, C. R. Mallszewskl, D. J. Pickup, J. E. Sims, R. M. L. Buller & J. VanSlyke. 1992. Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding a protein. Cell 71: 145–152.
- 68 Shieh, J. H., R. H. Peterson & M. A. Moore. 1993. Cytokines and dexamethasone modulation of IL-1 receptors on human neutrophils in vitro. J. Immunol. 150: 3515–3524.
- 69 O'Neill, L. A., T. A. Bird & J. Saklatvala. 1990. How does interleukin 1 activate cells? Interleukin 1 signal transduction. Immunol. Today 11: 392–394.
- 70 Mizel, S. B., 1990. How does interleukin 1 activate cells? Cyclic AMP and interleukin 1 signal transduction. Immunol. Today. 11: 390–391.
- 71 Rosoff, P. M., N. Savage & C. A. Dinarello. 1988. Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Cell 54: 73–81.
- 72 Rossi, B. 1993. IL-1 transduction signals. Eur. Cytokine Netw. 4: 181–187.
- 73 Mathias, S., A. Younes, C. C. Kan, I. Orlow, C. Joseph & R. N. Kolesnick. 1993. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta. Science 259: 519–522.
- 74 Kuno, K., K. Sukegawa, Y. Ishikawa, T. Orii & K. Matsushima. 1994. Acid shingomyelinase is not essential for the IL-1 and tumor necrosis factor receptor signaling pathway leading to NFkB activation. Int. Immunol. 6: 1269–1272.
- 75 Guesdon, F. & J. Saklatvala. 1991. Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27. J. Immunol. 147: 3402–3407.
- 76 Bird, T. A. & J. Saklatvala. 1990. Down-modulatior of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. J. Biol. Chem. 265: 235–240.
- 77 Stylianou, E., L. A. O'Neill, L. Rawlinson, M. R. Edbrooke, P. Woo & J. Saklatvala. 1992. Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. J. Biol. Chem. 267: 15836–15841.
- 78 Freshney, N. W., L. Rawlinson, F. Guesdon, E. Jones, S. Cowley, J. Hsuan & J. Saklatvala. 1994. Interleukin-1 actives a novel protein kinase cascade that results in phosphorylation of Hsp27. Cell 78: 1039–1049.
