Volume 868, Issue 1 p. 233-255

Molecular Diversity of K+ Channels

WILLIAM A. COETZEE

Corresponding Author

WILLIAM A. COETZEE

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

Corresponding authors: William A. Coetzee, D.Sc., Pediatric Cardiology, TH517, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–8518; fax: 212–263–1393; e-mail: [email protected] and Bernardo Rudy, Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–0431; fax: 212–689–9060; e-mail; [email protected]Search for more papers by this author
YIMY AMARILLO

YIMY AMARILLO

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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JOANNA CHIU

JOANNA CHIU

Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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ALAN CHOW

ALAN CHOW

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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DAVID LAU

DAVID LAU

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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TOM McCORMACK

TOM McCORMACK

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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HERMAN MORENA

HERMAN MORENA

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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MARCELA S. NADAL

MARCELA S. NADAL

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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ANDER OZAITA

ANDER OZAITA

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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DAVID POUNTNEY

DAVID POUNTNEY

Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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MICHAEL SAGANICH

MICHAEL SAGANICH

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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ELEAZAR VEGA-SAENZ DE MIERA

ELEAZAR VEGA-SAENZ DE MIERA

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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BERNARDO RUDY

BERNARDO RUDY

Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

Department Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA

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First published: 06 February 2006
Citations: 906

Abstract

ABSTRACT: K+ channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K+ channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editing and posttranslational modifications. In this chapter, we attempt to give an overview (mostly in tabular format) of the different genes coding for K+ channel principal and accessory subunits and their genealogical relationships. We discuss the possible correlation of different principal subunits with native K+ channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression. In addition, we devote a section to describing how diversity of K+ channels can be conferred by heteromultimer formation, accessory subunits, alternative splicing, RNA editing and posttranslational modifications. We trust that this collection of facts will be of use to those attempting to compare the properties of new subunits to the properties of others already known or to those interested in a comparison between native channels and cloned candidates.