Molecular Diversity of K+ Channels
WILLIAM A. COETZEE,
YIMY AMARILLO,
JOANNA CHIU,
ALAN CHOW,
DAVID LAU,
TOM McCORMACK,
HERMAN MORENA,
MARCELA S. NADAL,
ANDER OZAITA,
DAVID POUNTNEY,
MICHAEL SAGANICH,
ELEAZAR VEGA-SAENZ DE MIERA,
BERNARDO RUDY,
Corresponding Author
WILLIAM A. COETZEE
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Corresponding authors: William A. Coetzee, D.Sc., Pediatric Cardiology, TH517, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–8518; fax: 212–263–1393; e-mail: [email protected] and Bernardo Rudy, Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–0431; fax: 212–689–9060; e-mail; [email protected]Search for more papers by this authorYIMY AMARILLO
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorJOANNA CHIU
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorALAN CHOW
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorDAVID LAU
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorTOM McCORMACK
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorHERMAN MORENA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorMARCELA S. NADAL
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorANDER OZAITA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorDAVID POUNTNEY
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorMICHAEL SAGANICH
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorELEAZAR VEGA-SAENZ DE MIERA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorBERNARDO RUDY
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Department Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorWILLIAM A. COETZEE,
YIMY AMARILLO,
JOANNA CHIU,
ALAN CHOW,
DAVID LAU,
TOM McCORMACK,
HERMAN MORENA,
MARCELA S. NADAL,
ANDER OZAITA,
DAVID POUNTNEY,
MICHAEL SAGANICH,
ELEAZAR VEGA-SAENZ DE MIERA,
BERNARDO RUDY,
Corresponding Author
WILLIAM A. COETZEE
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Corresponding authors: William A. Coetzee, D.Sc., Pediatric Cardiology, TH517, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–8518; fax: 212–263–1393; e-mail: [email protected] and Bernardo Rudy, Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, New York 10016. Phone: 212–263–0431; fax: 212–689–9060; e-mail; [email protected]Search for more papers by this authorYIMY AMARILLO
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorJOANNA CHIU
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorALAN CHOW
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorDAVID LAU
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorTOM McCORMACK
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorHERMAN MORENA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorMARCELA S. NADAL
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorANDER OZAITA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorDAVID POUNTNEY
Department Pediatric Cardiology New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorMICHAEL SAGANICH
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorELEAZAR VEGA-SAENZ DE MIERA
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorBERNARDO RUDY
Department of Physiology and Neuroscience New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Department Biochemistry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Search for more papers by this authorAbstract
ABSTRACT: K+ channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K+ channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editing and posttranslational modifications. In this chapter, we attempt to give an overview (mostly in tabular format) of the different genes coding for K+ channel principal and accessory subunits and their genealogical relationships. We discuss the possible correlation of different principal subunits with native K+ channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression. In addition, we devote a section to describing how diversity of K+ channels can be conferred by heteromultimer formation, accessory subunits, alternative splicing, RNA editing and posttranslational modifications. We trust that this collection of facts will be of use to those attempting to compare the properties of new subunits to the properties of others already known or to those interested in a comparison between native channels and cloned candidates.
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[NOTE ADDED IN PROOF: After this paper was submitted, Wang et al. (1998, Science 282: 1890-1893) have presented strong evidence that KCNQ2 and KCNQ3 subunits form channels mediating the “M-current.”]
