Volume 953b, Issue 1 p. 157-164

Pharmacological Issues in the Treatment of Tuberculosis


Corresponding Author


Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA

Schools of Pharmacy and Medicine, University of Colorado, Denver, Colorado 80206, USA

Address for correspondence: Charles A. Peloquin, Pharm.D., Pharmacokinetics Laboratory, Room D-106, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206. Voice: 303-398-1427; fax: 303-270-2229; [email protected].Search for more papers by this author
First published: 10 February 2006
Citations: 50


Abstract: A thorough review of the clinical trial data combined with new in vitro experimental information may make the optimization of dosages of TB drugs possible. Several factors can affect the selection and dosage of TB drugs including hepatic and renal impairment, pregnancy, duration of disease before treatment, and extent of debilitation. Drug interactions and pharmacodynamics must be considered, and their roles are discussed.