Volume 966, Issue 1 p. 187-192

Hormone Replacement Therapy and Chronic Graft-versus-Host Disease Activity in Women Treated with Bone Marrow Transplantation for Hematologic Malignancies

ENRICO BALLEARI

Corresponding Author

ENRICO BALLEARI

Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy

Address for correspondence: Enrico Balleari, M.D., Department of Internal Medicine, University of Genoa, Viale Benedetto XV, No. 6, 16132 Genova, Italy. Voice: 00-39-010-3538964; fax: 00-39-010-3538649; [email protected].Search for more papers by this author
SIMONA GARRÈ

SIMONA GARRÈ

Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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MARIA TERESA VAN LINT

MARIA TERESA VAN LINT

Department of Hematology and Oncology, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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SIMONETTA SPINELLI

SIMONETTA SPINELLI

Department of Hematology and Oncology, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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SANDRA CHIODI

SANDRA CHIODI

Department of Hematology and Oncology, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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ENRICO REPETTO

ENRICO REPETTO

Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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GIULIO MASSA

GIULIO MASSA

Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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ANDREA BACIGALUPO

ANDREA BACIGALUPO

Department of Hematology and Oncology, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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RICCARDO GHIO

RICCARDO GHIO

Department of Internal Medicine, University of Genova and San Martino Hospital, 16132 Genoa, Italy

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First published: 24 January 2006
Citations: 20

Abstract

Abstract: Several lines of experimental evidence suggest that sex hormones may influence the development and activity of chronic graft-versus-host disease (cGVHD), which frequently occurs in patients undergoing allogeneic bone marrow transplantation (ABMT). Following ABMT, young women are commonly treated with hormone replacement therapy (HRT) because of irreversible gonadal failure. It seemed therefore worthwhile to investigate the effects of this therapy on the activity of cGVHD. Premenopausal women treated with ABMT for hematological malignancies between January 1997 and December 2000 were evaluated for cGVHD activity. They were divided into two groups, depending on whether or not they were treated with HRT. Seventy-one women qualified for the present study: 39 received HRT (treated group), while 32 did not (controls). In both groups of patients, cGVHD activity score was comparable before the start of HRT. No differences were observed in cGVHD activity score between the HRT group and controls after 3, 6, 12, and 24 months from the start of HRT. Furthermore, HRT did not induce any increase in the cGVHD activity score in the treated group of patients at any time from the start of HRT. According to present data, HRT did not appear to influence the activity of cGVHD in young women who underwent ABMT for hematological malignancies. Therefore, we can safely propose this therapy for women with gonadal failure after ABMT.