Dendritic Cells
Controllers of the Immune System and a New Promise for Immunotherapy
JACQUES BANCHEREAU
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorSOPHIE PACZESNY
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorPATRICK BLANCO
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorLYNDA BENNETT
Baylor Institute for Immunology Research, Dallas, Texas, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorVIRGINIA PASCUAL
Baylor Institute for Immunology Research, Dallas, Texas, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorJOSEPH FAY
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorCorresponding Author
A. KAROLINA PALUCKA
Baylor Institute for Immunology Research, Dallas, Texas, USA
Address for correspondence: A. Karolina Palucka, Baylor Insitute for Immunology Research, 3434 Live Oak, Dallas, TX 75204. Voice: 214-820-7450; fax: 214-820-4813. [email protected]Search for more papers by this authorJACQUES BANCHEREAU
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorSOPHIE PACZESNY
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorPATRICK BLANCO
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorLYNDA BENNETT
Baylor Institute for Immunology Research, Dallas, Texas, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorVIRGINIA PASCUAL
Baylor Institute for Immunology Research, Dallas, Texas, USA
University of Texas Southwestern Medical Center, Dallas, Texas, USA
Search for more papers by this authorJOSEPH FAY
Baylor Institute for Immunology Research, Dallas, Texas, USA
Search for more papers by this authorCorresponding Author
A. KAROLINA PALUCKA
Baylor Institute for Immunology Research, Dallas, Texas, USA
Address for correspondence: A. Karolina Palucka, Baylor Insitute for Immunology Research, 3434 Live Oak, Dallas, TX 75204. Voice: 214-820-7450; fax: 214-820-4813. [email protected]Search for more papers by this authorAbstract
Abstract: The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-α/β viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.
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