Probiotic Therapy in Radiation-Induced Intestinal Injury and Repair
Intestinal injury from ionizing radiation is a clinically important entity, as enteritis symptoms occur commonly after radiotherapy for pelvic malignancies. Preventative or therapeutic options for radiation enteritis are mostly unsatisfactory; however, available data suggests that probiotic bacteria—those which confer health benefit—may have therapeutic value. Previous reports from both human trials and animal models have evaluated various end points for probiotic usage in limiting radiation-associated intestinal damage. Newer data suggests that particular probiotics and/or their secreted or derived bacterial products may have unique radioprotective properties. We will review the area with a focus on new developments surrounding probiotic therapy in radiation-induced intestinal injury and repair.
2008. Medical prevention and treatment of acute and chronic radiation induced enteritis – is there any proven therapy? A short review.
. 2006. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.
2008. Toll-like receptors and intestinal epithelial repair.
Curr. Opin. Gastroenterol.
. 2005. Microbial regulation of intestinal radiosensitivity.
Proc. Natl. Acad. Sci. USA
. 2007. Radiation-induced Apoptosis is increased in MyD88-/- mice and the increase is reversed by PGE2 [abstract].
. 2006. Recommendations for probiotic use.
J. Clin. Gastroenterol.
. 2007. Use of probiotics for prevention of radiation-induced diarrhea.
World J. Gastroenterol.
. 1988. Preservation of intestinal integrity during radiotherapy using live Lactobacillus acidophilus cultures.
. 2008. Effects of probiotic lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial.
Int. J. Radiat. Oncol. Biol. Phys.
. 2007. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study.
Br. J. Cancer
. 2001. Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus in patients with radiation-induced diarrhoea.
Eur. J. Gastroenterol. Hepatol.
. 2006. Effects of probiotics on radiation-induced intestinal injury in rats.
. 1987. Effects of feeding lactobacillus GG on lethal irradiation in mice.
Diagn. Microbiol. Infect. Dis.
. 2007. Experimental radiotherapy-induced enteritis: a probiotic interventional study.
J. Dig. Dis.
. 2001. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.
2000. Review article: new insights into the pathogenesis of radiation-induced intestinal dysfunction.
Aliment. Pharmacol. Ther.
1990. A comprehensive study of the radiobiological response of the murine (BDF1) small intestine.
Int. J. Radiat. Biol.
. 2007. Effects of chronic 137Cs ingestion on barrier properties of jejunal epithelium in rats.
J. Toxicol. Environ. Health A
. 2004. Functional and structural alterations of epithelial barrier properties of rat ileum following X-irradiation.
Can. J. Physiol. Pharmacol.
. 1987. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells.
J. Dairy Sci.
. 2007. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth.
. 2002. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells.
J. Biol. Chem.
. 2004. Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation.
J. Clin. Invest.
. 2008. Lactobacillus rhamnosus GG prevents radiation induced small intestinal injury in a MyD88 independent, but COX2 dependent manner [abstract].
134(4 Supp 1): M1198.
. 2008. Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157:H7-induced changes in epithelial barrier function.
. 2008. Lactobacillus GG prevent impaired barrier function in intestinal epithelial cells [abstract].
134(4 Supp 1): M1737.
. 2008. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.
Am. J. Physiol. Gastrointest. Liver Physiol.
. 2008. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.