Onset of Odorant Receptors
Diego J. Rodriguez-Gil,
Helen B. Treloar,
Alexandra Miller, Aimee Two, Carrie Iwema, Charles A. Greer,
Diego J. Rodriguez-Gil
Neurosurgery
These two authors contributed equally to the work reported.
Search for more papers by this authorHelen B. Treloar
Neurosurgery
These two authors contributed equally to the work reported.
Search for more papers by this authorCharles A. Greer
Neurosurgery
Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Search for more papers by this authorDiego J. Rodriguez-Gil,
Helen B. Treloar,
Alexandra Miller, Aimee Two, Carrie Iwema, Charles A. Greer,
Diego J. Rodriguez-Gil
Neurosurgery
These two authors contributed equally to the work reported.
Search for more papers by this authorHelen B. Treloar
Neurosurgery
These two authors contributed equally to the work reported.
Search for more papers by this authorCharles A. Greer
Neurosurgery
Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Search for more papers by this authorAddress for correspondence: Charles A. Greer, PhD, Department of Neurosurgery, Yale University School of Medicine, P.O. Box 208082, New Haven, CT 06520-8082. Voice: +203.785.4034. [email protected]
Abstract
Odorant receptors are thought to be critical determinants of olfactory sensory neuron axon targeting and organization. Nonetheless, a systematic characterization of the onset of odorant receptor expression has not yet been done in the main olfactory epithelium. Here, we briefly review our current understanding regarding the onset of odorant receptor expression in the main olfactory epithelium and identify some of those questions which we believe must be of high priority for future study.
References
- 1 Cuschieri, A. & L.H. Bannister. 1975. The development of the olfactory mucosa in the mouse: electron microscopy. J. Anat. 119: 471–498.
- 2 Cuschieri, A. & L.H. Bannister. 1975. The development of the olfactory mucosa in the mouse: light microscopy. J. Anat. 119: 277–286.
- 3 Balmer, C.W. & A.S. LaMantia. 2005. Noses and neurons: induction, morphogenesis, and neuronal differentiation in the peripheral olfactory pathway. Dev. Dyn. 234: 464–481.
- 4 Feinstein, P. & P. Mombaerts. 2004. A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117: 817–831.
- 5 Hinds, J.W. & P.L. Hinds. 1976. Synapse formation in the mouse olfactory bulb. I. Quantitative studies. J. Comp. Neurol. 169: 15–40.
- 6 Treloar, H.B. et al . 2005. Expression of the neuronal calcium sensor protein NCS-1 in the developing mouse olfactory pathway. J. Comp. Neurol. 482: 201–216.
- 7 Chesler, A.T. et al . 2007. A G protein/cAMP signal cascade is required for axonal convergence into olfactory glomeruli. Proc. Natl. Acad. Sci. USA 104: 1039–1044.
- 8 Ressler, K.J., S.L. Sullivan & L.B. Buck. 1994. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79: 1245–1255.
- 9 Chess, A. et al . 1994. Allelic inactivation regulates olfactory receptor gene expression. Cell 78: 823–834.
- 10 Vassar, R. et al . 1994. Topographic organization of sensory projections to the olfactory bulb. Cell 79: 981–991.
- 11 Mombaerts, P. 2006. Axonal wiring in the mouse olfactory system. Annu. Rev. Cell Dev. Biol. 22: 713–737.
- 12 Treloar, H.B. et al . 2002. Specificity of glomerular targeting by olfactory sensory axons. J. Neurosci. 22: 2469–2477.
- 13 Mombaerts, P. 1996. Targeting olfaction. Curr. Opin. Neurobiol. 6: 481–486.
- 14 Wang, F. et al . 1998. Odorant receptors govern the formation of a precise topographic map. Cell 93: 47–60.
- 15 Imai, T., M. Suzuki & H. Sakano. 2006. Odorant receptor-derived cAMP signals direct axonal targeting. Science 314: 657–661.
- 16 Col, J.A. et al . 2007. Adenylyl cyclase-dependent axonal targeting in the olfactory system. Development 134: 2481–2489.
- 17 Zou, D.J. et al . 2007. Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. J. Neurosci. 27: 6675–6683.
- 18 Sullivan, S.L. et al . 1995. Target-independent pattern specification in the olfactory epithelium. Neuron 15: 779–789.
- 19 Schwarzenbacher, K. et al . 2004. Expression of olfactory receptors in the cribriform mesenchyme during prenatal development. Gene Expr. Patterns 4: 543–552.
- 20 Saito, H. et al . 1998. Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse. Brain Res. Dev. Brain Res. 110: 69–81.
- 21 Royal, S.J. & B. Key. 1999. Development of P2 olfactory glomeruli in P2-internal ribosome entry site-tau-LacZ transgenic mice. J. Neurosci. 19: 9856–9864.
- 22 Nef, P. et al . 1992. Spatial pattern of receptor expression in the olfactory epithelium. Proc. Natl. Acad. Sci. USA 89: 8948–8952.
- 23 Conzelmann, S. et al . 2001. Brain targeting and glomerulus formation of two olfactory neuron populations expressing related receptor types. Eur. J. Neurosci. 14: 1623–1632.
- 24 Tian, H. & M. Ma. 2008. Differential development of odorant receptor expression patterns in the olfactory epithelium: a quantitative analysis in the mouse septal organ. Dev. Neurobiol. 68: 476–486.
- 25 Tian, H. & M. Ma. 2008. Activity plays a role in eliminating olfactory sensory neurons expressing multiple odorant receptors in the mouse septal organ. Mol. Cell Neurosci. 38: 484–488.
