Volume 1239, Issue 1 p. 43-50

The orbitofrontal cortex, predicted value, and choice

Bernard W. Balleine

Bernard W. Balleine

Brain & Mind Research Institute, University of Sydney, Sydney, Australia.

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Beatrice K. Leung

Beatrice K. Leung

Brain & Mind Research Institute, University of Sydney, Sydney, Australia.

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Sean B. Ostlund

Sean B. Ostlund

Semel Institute, University of California, Los Angeles, Los Angeles, California

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First published: 06 December 2011
Citations: 58
Bernard Balleine, BMRI, 100 Mallet St, Camperdown, NSW 2050, Sydney, Australia. [email protected]

Abstract

Considerable evidence suggests that choice between goal-directed actions depends on two incentive processes encoding the reward value of the goal or outcome and the predicted value of an action based on outcome-related stimuli. Although incentive theories generally assume that these processes are mediated by a common associative mechanism, a number of recent findings suggest that they are dissociable; the reward value of an action is derived from consummatory experience with the outcome itself, whereas the predicted value of an action is based on the presence of outcome-associated stimuli from which estimates of the likelihood of an outcome are derived. Importantly, the orbitofrontal cortex (OFC) in rodents appears to mediate the effect of outcome-related stimuli on choice; OFC lesions disrupt the influence of Pavlovian stimuli on choice in tests of outcome-specific Pavlovian-instrumental transfer. However, the influence of outcome-related stimuli on choice involves a larger circuit including the OFC, the ventral striatum, and the amygdala. How these structures interact, however, is not yet fully understood and is an important question for future research.