Dissecting signaling and functions of adhesion G protein–coupled receptors
Gabriela Aust
Department of Surgery, Research Laboratories, University of Leipzig, Leipzig, Germany
Search for more papers by this authorDavide Calebiro
Institute of Pharmacology and Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
Search for more papers by this authorFelix B. Engel
Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany, and Laboratory of Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany
Search for more papers by this authorCaroline Formstone
MRC Centre for Developmental Neurobiology, King's College London, New Hunts House, London, United Kingdom
Search for more papers by this authorAndré Goffinet
Université Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
Search for more papers by this authorJörg Hamann
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorRobert J. Kittel
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany
Search for more papers by this authorInes Liebscher
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorHsi-Hsien Lin
Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Search for more papers by this authorKelly R. Monk
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri
Search for more papers by this authorAlexander Petrenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
Search for more papers by this authorXianhua Piao
Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorSimone Prömel
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorHelgi B. Schiöth
Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
Search for more papers by this authorThue W. Schwartz
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, and the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorMartin Stacey
Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
Search for more papers by this authorYuri A. Ushkaryov
Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom, and Medway School of Pharmacy, University of Kent, Chatham, United Kingdom
Search for more papers by this authorManja Wobus
Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany
Search for more papers by this authorUwe Wolfrum
Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University of Mainz, Mainz, Germany
Search for more papers by this authorLei Xu
University of Rochester Medical Center, Rochester, New York
Search for more papers by this authorTobias Langenhan
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany
Search for more papers by this authorGabriela Aust
Department of Surgery, Research Laboratories, University of Leipzig, Leipzig, Germany
Search for more papers by this authorDavide Calebiro
Institute of Pharmacology and Rudolf Virchow Center, DFG-Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
Search for more papers by this authorFelix B. Engel
Department of Cardiac Development and Remodelling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany, and Laboratory of Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany
Search for more papers by this authorCaroline Formstone
MRC Centre for Developmental Neurobiology, King's College London, New Hunts House, London, United Kingdom
Search for more papers by this authorAndré Goffinet
Université Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, Brussels, Belgium
Search for more papers by this authorJörg Hamann
Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Search for more papers by this authorRobert J. Kittel
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany
Search for more papers by this authorInes Liebscher
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorHsi-Hsien Lin
Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan
Search for more papers by this authorKelly R. Monk
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri
Search for more papers by this authorAlexander Petrenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
Search for more papers by this authorXianhua Piao
Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts
Search for more papers by this authorSimone Prömel
Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorHelgi B. Schiöth
Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
Search for more papers by this authorThue W. Schwartz
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, and the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorMartin Stacey
Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
Search for more papers by this authorYuri A. Ushkaryov
Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom, and Medway School of Pharmacy, University of Kent, Chatham, United Kingdom
Search for more papers by this authorManja Wobus
Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany
Search for more papers by this authorUwe Wolfrum
Cell and Matrix Biology, Institute of Zoology, Johannes Gutenberg University of Mainz, Mainz, Germany
Search for more papers by this authorLei Xu
University of Rochester Medical Center, Rochester, New York
Search for more papers by this authorTobias Langenhan
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany
Search for more papers by this authorAbstract
G protein–coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein–coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis–inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The “6th International Adhesion-GPCR Workshop,” held at the Institute of Physiology of the University of Würzburg on September 6–8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.
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