Metabotropic Glutamate 5 Receptor Antagonist MPEP Decreased Nicotine and Cocaine Self-Administration but Not Nicotine and Cocaine-Induced Facilitation of Brain Reward Function in Rats
Corresponding Author
P. J. KENNY
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Address for correspondence: P.J. Kenny, The Scripps Research Institute, Department of Neuropharmacology, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Voice: 858-784-7305; fax: 858-784-7405. [email protected]Search for more papers by this authorN. E. PATERSON
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorB. BOUTREL
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorS. SEMENOVA
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorA. A. HARRISON
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorF. GASPARINI
Nervous System Research, Novartis-Pharma AG, 4002 Basel, Switzerland
Search for more papers by this authorG. F. KOOB
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorP. D. SKOUBIS
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorA. MARKOU
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorCorresponding Author
P. J. KENNY
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Address for correspondence: P.J. Kenny, The Scripps Research Institute, Department of Neuropharmacology, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Voice: 858-784-7305; fax: 858-784-7405. [email protected]Search for more papers by this authorN. E. PATERSON
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorB. BOUTREL
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorS. SEMENOVA
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorA. A. HARRISON
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorF. GASPARINI
Nervous System Research, Novartis-Pharma AG, 4002 Basel, Switzerland
Search for more papers by this authorG. F. KOOB
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorP. D. SKOUBIS
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this authorA. MARKOU
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Search for more papers by this author
REFERENCES
- 1 Ungless, M.A. et al. 2001. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411: 583–587.
- 2 Kalivas, P.W. & P. Duffy. 1998. Repeated cocaine administration alters extracellular glutamate in the ventral tegmental area. J. Neurochem. 70: 1497–1502.
- 3 Wolf, M.E. 2003. Effects of psychomotor stimulants on glutamate receptor expression. Methods Mol. Med. 79: 13–31.
- 4 Mansvelder, H.D., J.R. Keath & D.S. McGehee. 2002. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 33: 905–919.
- 5 Mansvelder, H.D. & D.S. McGehee. 2000. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27: 349–357.
- 6 Harris, G.C. & G. Aston-Jones. 2003. Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment. Neuropsychopharmacology 28: 73–76.
- 7 Chiamulera, C. et al. 2001. Locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat. Neurosci. 4: 873–874.
- 8 Stewart, J., H. de Wit & R. Eikelboom. 1984. Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev. 91: 251–268.
- 9 Kenny, P.J. et al. 2003. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. Eur. J. Neurosci. 17: 191–195.
- 10 Markou, A. & G.F. Koob. 1992. Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiol. Behav. 51: 111–119.
- 11 Harrison, A.A., F. Gasparini & A. Markou. 2002. Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology (Berl) 160: 56–66.
- 12 Paterson, N.E. et al. 2003. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl.) 167(3): 257–264.