Volume 1075, Issue 1 p. 271-277

Circulating Nucleic Acids and Critical Illness

TIMOTHY H. RAINER

TIMOTHY H. RAINER

Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China

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NICOLE Y.L. LAM

NICOLE Y.L. LAM

Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China

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First published: 05 September 2006
Citations: 32
Address for correspondence: Dr. T. H. Rainer, Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR. Voice: +852-2632-1033; fax: +852-2648 -1469.
 e-mail: [email protected]

Abstract

Abstract: This article reviews some of the early work that has been performed to investigate the potential roles of circulating nucleic acids as prediction markers in acute illness and injury. Circulating DNA and RNA concentrations are elevated early in patients with trauma, stroke and ACS, and are generally highest in patients with a high risk of death. Circulating nucleic acids may be useful markers for the evaluation and risk-stratification of such patients.