Volume 1079, Issue 1 p. 320-326

TEDDY–The Environmental Determinants of Diabetes in the Young

An Observational Clinical Trial

WILLIAM A. HAGOPIAN

WILLIAM A. HAGOPIAN

Pacific Northwest Research Institute, Seattle, Washington 98122, USA

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ÅKE LERNMARK

ÅKE LERNMARK

University Hospital MAS, 20522 Malmö, Sweden

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MARIAN J. REWERS

MARIAN J. REWERS

University of Colorado, Denver, Colorado 80162, USA

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OLLI G. SIMELL

OLLI G. SIMELL

Turku University Central Hospital, Turku, 20520 Finland, USA

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JIN-XIONG SHE

JIN-XIONG SHE

Medical College of Georgia, Augusta, Georgia 30912, USA

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ANETTE G. ZIEGLER

ANETTE G. ZIEGLER

Diabetes Research Institute, 80804 Munich, Germany

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JEFFREY P. KRISCHER

JEFFREY P. KRISCHER

University of South Florida, Tampa, Florida 33612, USA

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BEENA AKOLKAR

BEENA AKOLKAR

National Institutes of Health, Bethesda, Maryland 20892, USA

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First published: 09 November 2006
Citations: 89
Address for correspondence: Åke Lernmark, Ph.D., CRC Lund University, Department of Clinical Sciences, University Hospital MAS, SE-205 02 Malmö, Sweden. Voice: +46 40 391901; fax: +46 40 39 19 19.
 e-mail: [email protected]

Abstract

Abstract: The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.