Volume 1108, Issue 1 p. 584-593

Autoantibodies in Nonautoimmune Individuals during Infections

TATIANA BERLIN

TATIANA BERLIN

Department of Medicine E, Meir Hospital, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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GISELE ZANDMAN-GODDARD

GISELE ZANDMAN-GODDARD

Department of Medicine C, Wolfson Medical Center, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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MIRI BLANK

MIRI BLANK

Center for Autoimmune Disease and Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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TORSTEN MATTHIAS

TORSTEN MATTHIAS

AESKU Institute, Research for Human Health, Wendelsheim, Germany

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SASCHA PFEIFFER

SASCHA PFEIFFER

AESKU Institute, Research for Human Health, Wendelsheim, Germany

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INGRID WEIS

INGRID WEIS

AESKU Institute, Research for Human Health, Wendelsheim, Germany

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ELIAS TOUBI

ELIAS TOUBI

Division of Clinical Immunology and Allergy, Bnai-Zion Medical Center, Haifa, Israel; Technion Faculty of Medicine, Haifa, Israel

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SHAM SINGH

SHAM SINGH

Rheumatic Diseases Unit, University of Cape Town Health Sciences Centre, Cape Town, and The Rosebank Clínic, Johannesburg, South Africa

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RONALD ASHERSON

RONALD ASHERSON

Rheumatic Diseases Unit, University of Cape Town Health Sciences Centre, Cape Town, and The Rosebank Clínic, Johannesburg, South Africa

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ABIGAIL FRASER

ABIGAIL FRASER

Department of Medicine E, Rabin Medical Center, Petach Tikvah, Israel

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BORIS GILBURD

BORIS GILBURD

Center for Autoimmune Disease and Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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TAL SAPIR

TAL SAPIR

Center for Autoimmune Disease and Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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YAIR LEVY

YAIR LEVY

Department of Medicine E, Meir Hospital, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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JANJA LUKAČ

JANJA LUKAČ

Department of Rheumatology, Ljubljana Medical Center, Ljubljana, Slovenia

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BLAŽ ROZMAN

BLAŽ ROZMAN

Department of Rheumatology, Ljubljana Medical Center, Ljubljana, Slovenia

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TANJA KVEDER

TANJA KVEDER

Department of Rheumatology, Ljubljana Medical Center, Ljubljana, Slovenia

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YEHUDA SHOENFELD

YEHUDA SHOENFELD

Center for Autoimmune Disease and Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Incumbent of the Laura Schwarz-Kipp Chair for Autoimmunity, Tel Aviv University, Tel Aviv, Israel

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First published: 29 August 2007
Citations: 57
Address for correspondence: Y. Shoenfeld, M.D., F.R.C.P. (Hon.), Department of Medicine B, Sheba Medical Center, Tel-Hashomer 52621, Israel. Voice: +972-3-5302652; fax: +972-3-5352855.
[email protected]

Abstract

Abstract: Infections can act as environmental triggers inducing or promoting autoimmune disease in genetically predisposed individuals. Identification of microbial peptides similar to self-tissues may by molecular mimicry, provide the inducing mechanism for an immune response. The aim of this study was to identify autoantibodies (autoAbs) in nonautoimmune individuals during acute bacterial, viral, or parasitic infections. Specific Abs or specific infections with an increased autoAb load may shed insight into the mechanisms of autoimmune disease. Sera from 88 patients with acute infections (41 bacterial, 23 viral, 17 parasitic, and 7 rickettsial) were tested by the ELISA method for antinuclear antibodies (ANA) 8 Pro, and Abs to thyroid peroxidase (TPO), thyroglobulin, phospholipids, annexin-V, laminin, anti–Saccharomyces cervisiae (ASCA), and prothrombin, along with 80 normal controls. Elevated titers of Abs to annexin-V and prothrombin were the most prevalent in viral, parasitic, and rickettsial infections and to laminin in viral and parasitic infections. Elevated titers of ASCA and ANA were found in viral and bacterial infections. Antiphospholipid Abs were found in parasitic and Q-fever infections. Thirty-four individuals harbored elevated titers of at least two Abs. An autoAb burden was detected in individuals with hepatitis A, hepatitis B, toxoplasma or Q-fever infections. In nonautoimmune individuals with various (bacterial, viral, parasitic, and rickettsial) infections, elevated titers of Abs to annexin-V, prothrombin, laminin, ASCA, ANA, and phospholipids were most frequently detected.