Volume 1150, Issue 1 p. 190-196

Update on Worldwide Efforts to Prevent Type 1 Diabetes

Jay S. Skyler

Jay S. Skyler

Diabetes Research Institute, Miami, Florida, USA

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for the Type 1 Diabetes TrialNet Study Group

for the Type 1 Diabetes TrialNet Study Group

Diabetes Research Institute, Miami, Florida, USA

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First published: 15 December 2008
Citations: 47
Address for correspondence: Jay S. Skyler, M.D., MACP, Diabetes Research Institute, University of Miami, Miller School of Medicine, 1450 NW 10th Avenue, Suite 3054 [P.O. Box 016960 (D-110)], Miami, FL 33101-6960. Voice: +305-243-6146; fax: 305-243-4484. [email protected]

Abstract

This paper reviews worldwide efforts to interdict the type 1 diabetes (T1D) disease process, during the stage of evolution of the disease prior to the time of disease onset. The goal of intervention before disease onset is to arrest immune destruction and thus prevent or delay clinical disease. In this regard, there have been several large-scale multicenter randomized controlled clinical trials designed to prevent T1D. These have tested nicotinamide, parenteral insulin, oral insulin, nasal insulin, and the elimination of cow's milk from infant feeding.