Evidence for circulatory benefits of resveratrol in humans
Rachel H.X. Wong
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorAlison M. Coates
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorJonathan D. Buckley
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorCorresponding Author
Peter R.C. Howe
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Clinical Nutrition Research Centre, University of Newcastle, Callaghan, New South Wales, Australia
Address for correspondence: Peter R.C. Howe, Clinical Nutrition Research Centre, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. [email protected]Search for more papers by this authorRachel H.X. Wong
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorAlison M. Coates
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorJonathan D. Buckley
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Search for more papers by this authorCorresponding Author
Peter R.C. Howe
Nutritional Physiology Research Centre, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Clinical Nutrition Research Centre, University of Newcastle, Callaghan, New South Wales, Australia
Address for correspondence: Peter R.C. Howe, Clinical Nutrition Research Centre, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia. [email protected]Search for more papers by this authorAbstract
Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.
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